The prognostic IDH1(R132) mutation is associated with reduced NADP(+)-dependent IDH activity in glioblastoma

Somatic mutations in the isocitrate dehydrogenase 1 gene (IDH1) occur at high frequency in gliomas and seem to be a prognostic factor for survival in glioblastoma patients. In our set of 98 glioblastoma patients, IDH1 (R132) mutations were associated with improved survival of 1 year on average, afte...

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Detalles Bibliográficos
Autores principales: Bleeker, Fonnet E., Atai, Nadia A., Lamba, Simona, Jonker, Ard, Rijkeboer, Denise, Bosch, Klazien S., Tigchelaar, Wikky, Troost, Dirk, Vandertop, W. Peter, Bardelli, Alberto, Van Noorden, Cornelis J. F.
Formato: Texto
Lenguaje:English
Publicado: Springer-Verlag 2010
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2841753/
https://www.ncbi.nlm.nih.gov/pubmed/20127344
http://dx.doi.org/10.1007/s00401-010-0645-6

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