Cargando…

Interleukin-6 is a significant predictor of radiographic knee osteoarthritis: The Chingford study

OBJECTIVE: There is a great need for identification of biomarkers that could improve the prediction of early osteoarthritis (OA). We undertook this study to determine whether circulating levels of interleukin-6 (IL-6), tumor necrosis factor α (TNFα), and C-reactive protein (CRP) can serve as useful...

Descripción completa

Detalles Bibliográficos
Autores principales: Livshits, Gregory, Zhai, Guangju, Hart, Deborah J, Kato, Bernet S, Wang, Huizhong, Williams, Frances M K, Spector, Tim D
Formato: Texto
Lenguaje:English
Publicado: Wiley Subscription Services, Inc., A Wiley Company 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2841820/
https://www.ncbi.nlm.nih.gov/pubmed/19565477
http://dx.doi.org/10.1002/art.24598
_version_ 1782179166023581696
author Livshits, Gregory
Zhai, Guangju
Hart, Deborah J
Kato, Bernet S
Wang, Huizhong
Williams, Frances M K
Spector, Tim D
author_facet Livshits, Gregory
Zhai, Guangju
Hart, Deborah J
Kato, Bernet S
Wang, Huizhong
Williams, Frances M K
Spector, Tim D
author_sort Livshits, Gregory
collection PubMed
description OBJECTIVE: There is a great need for identification of biomarkers that could improve the prediction of early osteoarthritis (OA). We undertook this study to determine whether circulating levels of interleukin-6 (IL-6), tumor necrosis factor α (TNFα), and C-reactive protein (CRP) can serve as useful markers of radiographic knee OA (RKOA) in a normal human population. METHODS: RKOA data were obtained from the cohort of the Chingford Study, a prospective population-based study of healthy, middle-aged British women. The RKOA-affected status of the subjects was assessed using the Kellgren/Lawrence (K/L) grade as determined on radiographs obtained at baseline (n = 908) and at 10 years and 15 years thereafter. Serum levels of CRP, IL-6, and TNFα were assayed at 5, 8, and 15 years, using high-sensitivity commercial assays. A K/L grade of ≥2 in either knee was used as the outcome measure. Statistical analyses included analysis of variance for repeated measurements and logistic regression models, together with longitudinal modeling of dichotomous responses. RESULTS: During 15 years of followup, the prevalence of RKOA (K/L grade ≥2) increased from 14.7% to 48.7% (P < 0.00001 versus baseline). The body mass index (BMI) and circulating levels of CRP and IL-6 were consistently and significantly higher in subjects diagnosed as having RKOA. When multiple logistic regression was applied to the data, the variables of older age (P = 3.93 × 10(−5)), higher BMI at baseline (P = 0.0003), and increased levels of IL-6 at year 5 (P = 0.0129) were determined to be independent predictors of the appearance of RKOA at year 10. The results were fully confirmed using longitudinal modeling of repeated measurements of the data obtained at 3 visits. The odds ratio for RKOA in subjects whose IL-6 levels were in the fourth quartile of increasing levels (versus the first quartile) was 2.74 (95% confidence interval 1.94–3.87). CONCLUSION: This followup study showed that individuals were more likely to be diagnosed as having RKOA if they had a higher BMI and increased circulating levels of IL-6. These results should stimulate more work on IL-6 as a potential therapeutic target.
format Text
id pubmed-2841820
institution National Center for Biotechnology Information
language English
publishDate 2009
publisher Wiley Subscription Services, Inc., A Wiley Company
record_format MEDLINE/PubMed
spelling pubmed-28418202010-03-27 Interleukin-6 is a significant predictor of radiographic knee osteoarthritis: The Chingford study Livshits, Gregory Zhai, Guangju Hart, Deborah J Kato, Bernet S Wang, Huizhong Williams, Frances M K Spector, Tim D Arthritis Rheum Osteoarthritis OBJECTIVE: There is a great need for identification of biomarkers that could improve the prediction of early osteoarthritis (OA). We undertook this study to determine whether circulating levels of interleukin-6 (IL-6), tumor necrosis factor α (TNFα), and C-reactive protein (CRP) can serve as useful markers of radiographic knee OA (RKOA) in a normal human population. METHODS: RKOA data were obtained from the cohort of the Chingford Study, a prospective population-based study of healthy, middle-aged British women. The RKOA-affected status of the subjects was assessed using the Kellgren/Lawrence (K/L) grade as determined on radiographs obtained at baseline (n = 908) and at 10 years and 15 years thereafter. Serum levels of CRP, IL-6, and TNFα were assayed at 5, 8, and 15 years, using high-sensitivity commercial assays. A K/L grade of ≥2 in either knee was used as the outcome measure. Statistical analyses included analysis of variance for repeated measurements and logistic regression models, together with longitudinal modeling of dichotomous responses. RESULTS: During 15 years of followup, the prevalence of RKOA (K/L grade ≥2) increased from 14.7% to 48.7% (P < 0.00001 versus baseline). The body mass index (BMI) and circulating levels of CRP and IL-6 were consistently and significantly higher in subjects diagnosed as having RKOA. When multiple logistic regression was applied to the data, the variables of older age (P = 3.93 × 10(−5)), higher BMI at baseline (P = 0.0003), and increased levels of IL-6 at year 5 (P = 0.0129) were determined to be independent predictors of the appearance of RKOA at year 10. The results were fully confirmed using longitudinal modeling of repeated measurements of the data obtained at 3 visits. The odds ratio for RKOA in subjects whose IL-6 levels were in the fourth quartile of increasing levels (versus the first quartile) was 2.74 (95% confidence interval 1.94–3.87). CONCLUSION: This followup study showed that individuals were more likely to be diagnosed as having RKOA if they had a higher BMI and increased circulating levels of IL-6. These results should stimulate more work on IL-6 as a potential therapeutic target. Wiley Subscription Services, Inc., A Wiley Company 2009-07 /pmc/articles/PMC2841820/ /pubmed/19565477 http://dx.doi.org/10.1002/art.24598 Text en Copyright © 2009 American College of Rheumatology http://creativecommons.org/licenses/by/2.5/ Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation.
spellingShingle Osteoarthritis
Livshits, Gregory
Zhai, Guangju
Hart, Deborah J
Kato, Bernet S
Wang, Huizhong
Williams, Frances M K
Spector, Tim D
Interleukin-6 is a significant predictor of radiographic knee osteoarthritis: The Chingford study
title Interleukin-6 is a significant predictor of radiographic knee osteoarthritis: The Chingford study
title_full Interleukin-6 is a significant predictor of radiographic knee osteoarthritis: The Chingford study
title_fullStr Interleukin-6 is a significant predictor of radiographic knee osteoarthritis: The Chingford study
title_full_unstemmed Interleukin-6 is a significant predictor of radiographic knee osteoarthritis: The Chingford study
title_short Interleukin-6 is a significant predictor of radiographic knee osteoarthritis: The Chingford study
title_sort interleukin-6 is a significant predictor of radiographic knee osteoarthritis: the chingford study
topic Osteoarthritis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2841820/
https://www.ncbi.nlm.nih.gov/pubmed/19565477
http://dx.doi.org/10.1002/art.24598
work_keys_str_mv AT livshitsgregory interleukin6isasignificantpredictorofradiographickneeosteoarthritisthechingfordstudy
AT zhaiguangju interleukin6isasignificantpredictorofradiographickneeosteoarthritisthechingfordstudy
AT hartdeborahj interleukin6isasignificantpredictorofradiographickneeosteoarthritisthechingfordstudy
AT katobernets interleukin6isasignificantpredictorofradiographickneeosteoarthritisthechingfordstudy
AT wanghuizhong interleukin6isasignificantpredictorofradiographickneeosteoarthritisthechingfordstudy
AT williamsfrancesmk interleukin6isasignificantpredictorofradiographickneeosteoarthritisthechingfordstudy
AT spectortimd interleukin6isasignificantpredictorofradiographickneeosteoarthritisthechingfordstudy