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Analysis of microsatellite polymorphisms within the GLC1F locus in Japanese patients with normal tension glaucoma
PURPOSE: To investigate whether the GLC1F locus is associated with normal tension glaucoma (NTG) in Japanese patients. METHODS: We recruited 242 unrelated Japanese subjects, including, 141 NTG patients and 101 healthy controls. The patients exhibiting a comparatively early onset were selected as the...
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Molecular Vision
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2842094/ https://www.ncbi.nlm.nih.gov/pubmed/20309402 |
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| author | Murakami, Kaori Meguro, Akira Ota, Masao Shiota, Tomoko Nomura, Naoko Kashiwagi, Kenji Mabuchi, Fumihiko Iijima, Hiroyuki Kawase, Kazuhide Yamamoto, Tetsuya Nakamura, Makoto Negi, Akira Sagara, Takeshi Nishida, Teruo Inatani, Masaru Tanihara, Hidenobu Aihara, Makoto Araie, Makoto Fukuchi, Takeo Abe, Haruki Higashide, Tomomi Sugiyama, Kazuhisa Kanamoto, Takashi Kiuchi, Yoshiaki Iwase, Aiko Ohno, Shigeaki Inoko, Hidetoshi Mizuki, Nobuhisa |
| author_facet | Murakami, Kaori Meguro, Akira Ota, Masao Shiota, Tomoko Nomura, Naoko Kashiwagi, Kenji Mabuchi, Fumihiko Iijima, Hiroyuki Kawase, Kazuhide Yamamoto, Tetsuya Nakamura, Makoto Negi, Akira Sagara, Takeshi Nishida, Teruo Inatani, Masaru Tanihara, Hidenobu Aihara, Makoto Araie, Makoto Fukuchi, Takeo Abe, Haruki Higashide, Tomomi Sugiyama, Kazuhisa Kanamoto, Takashi Kiuchi, Yoshiaki Iwase, Aiko Ohno, Shigeaki Inoko, Hidetoshi Mizuki, Nobuhisa |
| author_sort | Murakami, Kaori |
| collection | PubMed |
| description | PURPOSE: To investigate whether the GLC1F locus is associated with normal tension glaucoma (NTG) in Japanese patients. METHODS: We recruited 242 unrelated Japanese subjects, including, 141 NTG patients and 101 healthy controls. The patients exhibiting a comparatively early onset were selected as they suggest that genetic factors may show stronger involvement. Genotyping and assessment of allelic diversity was performed on 11 highly polymorphic microsatellite markers in and around the GLC1F locus. RESULTS: Individuals carrying the 163 allele of D7S1277i had a statistically significant increased risk of NTG (p=0.0013, pc=0.016, OR=2.47, 95%CI=1.42–4.30). None of the other markers identified significant loci (pc>0.05) after Bonferroni’s correction. CONCLUSIONS: These findings suggested that the genes in the GLC1F locus may be associated with the pathogenesis of NTG. |
| format | Text |
| id | pubmed-2842094 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2010 |
| publisher | Molecular Vision |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-28420942010-03-22 Analysis of microsatellite polymorphisms within the GLC1F locus in Japanese patients with normal tension glaucoma Murakami, Kaori Meguro, Akira Ota, Masao Shiota, Tomoko Nomura, Naoko Kashiwagi, Kenji Mabuchi, Fumihiko Iijima, Hiroyuki Kawase, Kazuhide Yamamoto, Tetsuya Nakamura, Makoto Negi, Akira Sagara, Takeshi Nishida, Teruo Inatani, Masaru Tanihara, Hidenobu Aihara, Makoto Araie, Makoto Fukuchi, Takeo Abe, Haruki Higashide, Tomomi Sugiyama, Kazuhisa Kanamoto, Takashi Kiuchi, Yoshiaki Iwase, Aiko Ohno, Shigeaki Inoko, Hidetoshi Mizuki, Nobuhisa Mol Vis Research Article PURPOSE: To investigate whether the GLC1F locus is associated with normal tension glaucoma (NTG) in Japanese patients. METHODS: We recruited 242 unrelated Japanese subjects, including, 141 NTG patients and 101 healthy controls. The patients exhibiting a comparatively early onset were selected as they suggest that genetic factors may show stronger involvement. Genotyping and assessment of allelic diversity was performed on 11 highly polymorphic microsatellite markers in and around the GLC1F locus. RESULTS: Individuals carrying the 163 allele of D7S1277i had a statistically significant increased risk of NTG (p=0.0013, pc=0.016, OR=2.47, 95%CI=1.42–4.30). None of the other markers identified significant loci (pc>0.05) after Bonferroni’s correction. CONCLUSIONS: These findings suggested that the genes in the GLC1F locus may be associated with the pathogenesis of NTG. Molecular Vision 2010-03-17 /pmc/articles/PMC2842094/ /pubmed/20309402 Text en Copyright © 2010 Molecular Vision. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| spellingShingle | Research Article Murakami, Kaori Meguro, Akira Ota, Masao Shiota, Tomoko Nomura, Naoko Kashiwagi, Kenji Mabuchi, Fumihiko Iijima, Hiroyuki Kawase, Kazuhide Yamamoto, Tetsuya Nakamura, Makoto Negi, Akira Sagara, Takeshi Nishida, Teruo Inatani, Masaru Tanihara, Hidenobu Aihara, Makoto Araie, Makoto Fukuchi, Takeo Abe, Haruki Higashide, Tomomi Sugiyama, Kazuhisa Kanamoto, Takashi Kiuchi, Yoshiaki Iwase, Aiko Ohno, Shigeaki Inoko, Hidetoshi Mizuki, Nobuhisa Analysis of microsatellite polymorphisms within the GLC1F locus in Japanese patients with normal tension glaucoma |
| title | Analysis of microsatellite polymorphisms within the GLC1F locus in Japanese patients with normal tension glaucoma |
| title_full | Analysis of microsatellite polymorphisms within the GLC1F locus in Japanese patients with normal tension glaucoma |
| title_fullStr | Analysis of microsatellite polymorphisms within the GLC1F locus in Japanese patients with normal tension glaucoma |
| title_full_unstemmed | Analysis of microsatellite polymorphisms within the GLC1F locus in Japanese patients with normal tension glaucoma |
| title_short | Analysis of microsatellite polymorphisms within the GLC1F locus in Japanese patients with normal tension glaucoma |
| title_sort | analysis of microsatellite polymorphisms within the glc1f locus in japanese patients with normal tension glaucoma |
| topic | Research Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2842094/ https://www.ncbi.nlm.nih.gov/pubmed/20309402 |
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