Cargando…

Endothelial-Rac1 Is Not Required for Tumor Angiogenesis unless αvβ3-Integrin Is Absent

Endothelial cell migration is an essential aspect of tumor angiogenesis. Rac1 activity is needed for cell migration in vitro implying a requirement for this molecule in angiogenesis in vivo. However, a precise role for Rac1 in tumor angiogenesis has never been addressed. Here we show that depletion...

Descripción completa

Detalles Bibliográficos
Autores principales:	D'Amico, Gabriela, Robinson, Stephen D., Germain, Mitchel, Reynolds, Louise E., Thomas, Gareth J., Elia, George, Saunders, Garry, Fruttiger, Marcus, Tybulewicz, Victor, Mavria, Georgia, Hodivala-Dilke, Kairbaan M.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2842301/ https://www.ncbi.nlm.nih.gov/pubmed/20339539 http://dx.doi.org/10.1371/journal.pone.0009766

Ejemplares similares

Acute, but not constitutive, loss of endothelial β3-integrin inhibits tumour growth and angiogenesis
por: Steri, Veronica, et al.
Publicado: (2013)

“Splitting the matrix”: intussusceptive angiogenesis meets MT1‐MMP
por: D'Amico, Gabriela, et al.
Publicado: (2019)

Dual role of pericyte α6β1-integrin in tumour blood vessels
por: Reynolds, Louise E., et al.
Publicado: (2017)

Novel roles for integrins in tumour angiogenesis
por: Germain, M, et al.
Publicado: (2006)

Endothelial FAK is required for tumour angiogenesis
por: Tavora, Bernardo, et al.
Publicado: (2010)

Endothelial FAK is required for tumour angiogenesis
por: Tavora, Bernardo, et al.
Publicado: (2016)

Novel Roles for α3β1 Integrin as a Regulator of Cytoskeletal Assembly and as a Trans-dominant Inhibitor of Integrin Receptor Function in Mouse Keratinocytes
por: Hodivala-Dilke, Kairbaan M., et al.
Publicado: (1998)

α3β1 Integrin Is Required for Normal Development of the Epidermal Basement Membrane
por: DiPersio, C. Michael, et al.
Publicado: (1997)

Stromal Claudin14-Heterozygosity, but Not Deletion, Increases Tumour Blood Leakage without Affecting Tumour Growth
por: Baker, Marianne, et al.
Publicado: (2013)

Fascin 1 is dispensable for developmental and tumour angiogenesis
por: Ma, Yafeng, et al.
Publicado: (2013)

αvβ3 integrin spatially regulates VASP and RIAM to control adhesion dynamics and migration
por: Worth, Daniel C., et al.
Publicado: (2010)

Endogenous ribosomal protein L29 (RPL29): a newly identified regulator of angiogenesis in mice
por: Jones, Dylan T., et al.
Publicado: (2013)

Correction to: Phosphorylation of pericyte FAK‑Y861 affects tumour cell apoptosis and tumour blood vessel regression
por: Lees, Delphine M., et al.
Publicado: (2021)

Phosphorylation of pericyte FAK-Y861 affects tumour cell apoptosis and tumour blood vessel regression
por: Lees, Delphine M., et al.
Publicado: (2021)

Tumour-associated endothelial-FAK correlated with molecular sub-type and prognostic factors in invasive breast cancer
por: Alexopoulou, Annika N, et al.
Publicado: (2014)

Humancentric: technology fails unless it means something to someone
por: Saunders, Mike
Publicado: (2020)

Focal Adhesion Kinase (FAK) tyrosine 397E mutation restores the vascular leakage defect in endothelium‐specific FAK‐kinase dead mice
por: Alexopoulou, Annika N, et al.
Publicado: (2017)

Repurposing an anti‐cancer agent for the treatment of hypertrophic heart disease
por: Dukinfield, Matthew, et al.
Publicado: (2019)

Improved Immunotherapy Efficacy by Vascular Modulation
por: Newport, Emma L., et al.
Publicado: (2021)

Pericyte FAK negatively regulates Gas6/Axl signalling to suppress tumour angiogenesis and tumour growth
por: Lechertier, Tanguy, et al.
Publicado: (2020)

Pancreatic stellate cells regulate blood vessel density in the stroma of pancreatic ductal adenocarcinoma
por: Di Maggio, Francesco, et al.
Publicado: (2016)

Author Correction: Pericyte FAK negatively regulates Gas6/Axl signalling to suppress tumour angiogenesis and tumour growth
por: Lechertier, Tanguy, et al.
Publicado: (2023)

Association of Low Tumor Endothelial Cell pY397–Focal Adhesion Kinase Expression With Survival in Patients With Neoadjuvant-Treated Locally Advanced Breast Cancer
por: Roy-Luzarraga, Marina, et al.
Publicado: (2020)

Tumour angiogenesis is reduced in the Tc1 mouse model of Down Syndrome
por: Reynolds, Louise E., et al.
Publicado: (2010)

Schematic memories develop quickly, but are not expressed unless necessary
por: Tompary, Alexa, et al.
Publicado: (2020)

FAK-heterozygous mice display enhanced tumour angiogenesis
por: Kostourou, Vassiliki, et al.
Publicado: (2013)

Never Repeat the Same Trick Twice—Unless it is Cognitively Impenetrable
por: Ekroll, Vebjørn, et al.
Publicado: (2018)

A Cage Is a Cage, Unless You Educate. Rhetoric Negatively Impacts Support for a Novel Housing System for Laying Hens Unless the Public Are Educated
por: Nolan, Huw R. J., et al.
Publicado: (2022)

β1 integrin activates Rac1 in Schwann cells to generate radial lamellae during axonal sorting and myelination
por: Nodari, Alessandro, et al.
Publicado: (2007)

Ocular antigen does not cause disease unless presented in the context of inflammation
por: Voigt, Valentina, et al.
Publicado: (2017)

Facial impression of trustworthiness biases statement credibility unless suppressed by facemask
por: Marini, Marco, et al.
Publicado: (2022)

C-type natriuretic peptide co-ordinates cardiac structure and function
por: Moyes, Amie J, et al.
Publicado: (2020)

Gene Expression Analysis in Human Breast Cancer Associated Blood Vessels
por: Jones, Dylan T., et al.
Publicado: (2012)

Universal COVID-19 vaccination cost saving unless anaphylaxis rate high
Publicado: (2021)

Unless we address the inequity in global health, then the world will not be prepared for the next pandemic
por: Olatunbosun-Alakija, Ayoade
Publicado: (2021)

Implementation of the “No ICU – Unless” approach in postoperative neurosurgical management in times of COVID-19
por: Qasem, Lina-Elisabeth, et al.
Publicado: (2022)

Research—What is it good for? Absolutely nothing… unless it is used to inform policy and practice
por: White, Howard, et al.
Publicado: (2022)

Implementation of the “No ICU – Unless” approach in postoperative neurosurgical management in times of Covid-19
por: Qasem, L.-E., et al.
Publicado: (2022)

Infinitely large, randomly wired sensors cannot predict their input unless they are close to deterministic
por: Marzen, Sarah
Publicado: (2018)

The functional brain favours segregated modular connectivity at old age unless affected by neurodegeneration
por: Chen, Xue, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_v05nmt97f8ok8j3a8mhfor0luf