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Impact of carbohydrate restriction with and without fatty acid loading on myocardial (18)F-FDG uptake during PET: A randomized controlled trial

BACKGROUND: Low-carbohydrate (LC) and high-fat, low-carbohydrate (HFLC) dietary preparations may enhance (18)F-FDG-PET-based imaging of small, inflamed structures near the heart by suppressing myocardial FDG signal. We compared myocardial (18)F-FDG uptake in patients randomized to LC, HFLC, and unre...

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Autores principales: Cheng, Victor Y., Slomka, Piotr J., Ahlen, Marie, Thomson, Louise E. J., Waxman, Alan D., Berman, Daniel S.
Formato: Texto
Lenguaje:English
Publicado: Springer-Verlag 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2842563/
https://www.ncbi.nlm.nih.gov/pubmed/20013165
http://dx.doi.org/10.1007/s12350-009-9179-5
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author Cheng, Victor Y.
Slomka, Piotr J.
Ahlen, Marie
Thomson, Louise E. J.
Waxman, Alan D.
Berman, Daniel S.
author_facet Cheng, Victor Y.
Slomka, Piotr J.
Ahlen, Marie
Thomson, Louise E. J.
Waxman, Alan D.
Berman, Daniel S.
author_sort Cheng, Victor Y.
collection PubMed
description BACKGROUND: Low-carbohydrate (LC) and high-fat, low-carbohydrate (HFLC) dietary preparations may enhance (18)F-FDG-PET-based imaging of small, inflamed structures near the heart by suppressing myocardial FDG signal. We compared myocardial (18)F-FDG uptake in patients randomized to LC, HFLC, and unrestricted (UR) preparations prior to (18)F-FDG-PET. METHODS AND RESULTS: We randomized 63 outpatients referred for oncologic (18)F-FDG-PET to LC, HFLC, or UR dietary preparations (1:1:1 allocation) starting the evening before PET. After eating dinner according to instructions, UR and LC patients fasted until FDG injection (mean time 745 minutes for UR, 899 minutes for LC), and HFLC patients drank a fatty drink 60-70 minutes prior to FDG injection. Attenuation-corrected PET imaging was performed 60 minutes after FDG administration. Maximal myocardial standard uptake values (MyoSUV(max)) were systematically measured in axial view and compared between the three groups. Using UR patients as reference, mean MyoSUV(max) was lower in LC patients (3.3 ± 2.7 vs 6.2 ± 5.2, P = .03) but not in HFLC patients (5.5 ± 4.2, P = .63). Ratios of MyoSUV(max) to liver SUV(max), calculated to control for background uptake, were not significantly different amongst the groups (1.9 ± 2.1 LC, 2.6 ± 2.3 HFLC, 3.6 ± 3.5 UR). CONCLUSION: In this small randomized controlled trial using UR diet as reference, LC dietary preparation followed by extended fasting resulted in significant myocardial uptake suppression.
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spelling pubmed-28425632010-03-26 Impact of carbohydrate restriction with and without fatty acid loading on myocardial (18)F-FDG uptake during PET: A randomized controlled trial Cheng, Victor Y. Slomka, Piotr J. Ahlen, Marie Thomson, Louise E. J. Waxman, Alan D. Berman, Daniel S. J Nucl Cardiol Original Article BACKGROUND: Low-carbohydrate (LC) and high-fat, low-carbohydrate (HFLC) dietary preparations may enhance (18)F-FDG-PET-based imaging of small, inflamed structures near the heart by suppressing myocardial FDG signal. We compared myocardial (18)F-FDG uptake in patients randomized to LC, HFLC, and unrestricted (UR) preparations prior to (18)F-FDG-PET. METHODS AND RESULTS: We randomized 63 outpatients referred for oncologic (18)F-FDG-PET to LC, HFLC, or UR dietary preparations (1:1:1 allocation) starting the evening before PET. After eating dinner according to instructions, UR and LC patients fasted until FDG injection (mean time 745 minutes for UR, 899 minutes for LC), and HFLC patients drank a fatty drink 60-70 minutes prior to FDG injection. Attenuation-corrected PET imaging was performed 60 minutes after FDG administration. Maximal myocardial standard uptake values (MyoSUV(max)) were systematically measured in axial view and compared between the three groups. Using UR patients as reference, mean MyoSUV(max) was lower in LC patients (3.3 ± 2.7 vs 6.2 ± 5.2, P = .03) but not in HFLC patients (5.5 ± 4.2, P = .63). Ratios of MyoSUV(max) to liver SUV(max), calculated to control for background uptake, were not significantly different amongst the groups (1.9 ± 2.1 LC, 2.6 ± 2.3 HFLC, 3.6 ± 3.5 UR). CONCLUSION: In this small randomized controlled trial using UR diet as reference, LC dietary preparation followed by extended fasting resulted in significant myocardial uptake suppression. Springer-Verlag 2009-12-15 2010 /pmc/articles/PMC2842563/ /pubmed/20013165 http://dx.doi.org/10.1007/s12350-009-9179-5 Text en © The Author(s) 2009 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Original Article
Cheng, Victor Y.
Slomka, Piotr J.
Ahlen, Marie
Thomson, Louise E. J.
Waxman, Alan D.
Berman, Daniel S.
Impact of carbohydrate restriction with and without fatty acid loading on myocardial (18)F-FDG uptake during PET: A randomized controlled trial
title Impact of carbohydrate restriction with and without fatty acid loading on myocardial (18)F-FDG uptake during PET: A randomized controlled trial
title_full Impact of carbohydrate restriction with and without fatty acid loading on myocardial (18)F-FDG uptake during PET: A randomized controlled trial
title_fullStr Impact of carbohydrate restriction with and without fatty acid loading on myocardial (18)F-FDG uptake during PET: A randomized controlled trial
title_full_unstemmed Impact of carbohydrate restriction with and without fatty acid loading on myocardial (18)F-FDG uptake during PET: A randomized controlled trial
title_short Impact of carbohydrate restriction with and without fatty acid loading on myocardial (18)F-FDG uptake during PET: A randomized controlled trial
title_sort impact of carbohydrate restriction with and without fatty acid loading on myocardial (18)f-fdg uptake during pet: a randomized controlled trial
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2842563/
https://www.ncbi.nlm.nih.gov/pubmed/20013165
http://dx.doi.org/10.1007/s12350-009-9179-5
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