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Tuberculosis in Dr Granville's mummy: a molecular re-examination of the earliest known Egyptian mummy to be scientifically examined and given a medical diagnosis

‘Dr Granville's mummy’ was described to the Royal Society of London in 1825 and was the first ancient Egyptian mummy to be subjected to a scientific autopsy. The remains are those of a woman, Irtyersenu, aged about 50, from the necropolis of Thebes and dated to about 600 BC. Augustus Bozzi Gran...

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Autores principales: Donoghue, Helen D., Lee, Oona Y.-C., Minnikin, David E., Besra, Gurdyal S., Taylor, John H., Spigelman, Mark
Formato: Texto
Lenguaje:English
Publicado: The Royal Society 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2842630/
https://www.ncbi.nlm.nih.gov/pubmed/19793751
http://dx.doi.org/10.1098/rspb.2009.1484
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author Donoghue, Helen D.
Lee, Oona Y.-C.
Minnikin, David E.
Besra, Gurdyal S.
Taylor, John H.
Spigelman, Mark
author_facet Donoghue, Helen D.
Lee, Oona Y.-C.
Minnikin, David E.
Besra, Gurdyal S.
Taylor, John H.
Spigelman, Mark
author_sort Donoghue, Helen D.
collection PubMed
description ‘Dr Granville's mummy’ was described to the Royal Society of London in 1825 and was the first ancient Egyptian mummy to be subjected to a scientific autopsy. The remains are those of a woman, Irtyersenu, aged about 50, from the necropolis of Thebes and dated to about 600 BC. Augustus Bozzi Granville (1783–1872), an eminent physician and obstetrician, described many organs still in situ and attributed the cause of death to a tumour of the ovary. However, subsequent histological investigations indicate that the tumour is a benign cystadenoma. Histology of the lungs demonstrated a potentially fatal pulmonary exudate and earlier studies attempted to associate this with particular disease conditions. Palaeopathology and ancient DNA analyses show that tuberculosis was widespread in ancient Egypt, so a systematic search for tuberculosis was made, using specific DNA and lipid biomarker analyses. Clear evidence for Mycobacterium tuberculosis complex DNA was obtained in lung tissue and gall bladder samples, based on nested PCR of the IS6110 locus. Lung and femurs were positive for specific M. tuberculosis complex cell-wall mycolic acids, demonstrated by high-performance liquid chromatography of pyrenebutyric acid–pentafluorobenzyl mycolates. Therefore, tuberculosis is likely to have been the major cause of death of Irtyersenu.
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spelling pubmed-28426302010-03-23 Tuberculosis in Dr Granville's mummy: a molecular re-examination of the earliest known Egyptian mummy to be scientifically examined and given a medical diagnosis Donoghue, Helen D. Lee, Oona Y.-C. Minnikin, David E. Besra, Gurdyal S. Taylor, John H. Spigelman, Mark Proc Biol Sci Research articles ‘Dr Granville's mummy’ was described to the Royal Society of London in 1825 and was the first ancient Egyptian mummy to be subjected to a scientific autopsy. The remains are those of a woman, Irtyersenu, aged about 50, from the necropolis of Thebes and dated to about 600 BC. Augustus Bozzi Granville (1783–1872), an eminent physician and obstetrician, described many organs still in situ and attributed the cause of death to a tumour of the ovary. However, subsequent histological investigations indicate that the tumour is a benign cystadenoma. Histology of the lungs demonstrated a potentially fatal pulmonary exudate and earlier studies attempted to associate this with particular disease conditions. Palaeopathology and ancient DNA analyses show that tuberculosis was widespread in ancient Egypt, so a systematic search for tuberculosis was made, using specific DNA and lipid biomarker analyses. Clear evidence for Mycobacterium tuberculosis complex DNA was obtained in lung tissue and gall bladder samples, based on nested PCR of the IS6110 locus. Lung and femurs were positive for specific M. tuberculosis complex cell-wall mycolic acids, demonstrated by high-performance liquid chromatography of pyrenebutyric acid–pentafluorobenzyl mycolates. Therefore, tuberculosis is likely to have been the major cause of death of Irtyersenu. The Royal Society 2010-01-07 2009-09-30 /pmc/articles/PMC2842630/ /pubmed/19793751 http://dx.doi.org/10.1098/rspb.2009.1484 Text en © 2009 The Royal Society http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research articles
Donoghue, Helen D.
Lee, Oona Y.-C.
Minnikin, David E.
Besra, Gurdyal S.
Taylor, John H.
Spigelman, Mark
Tuberculosis in Dr Granville's mummy: a molecular re-examination of the earliest known Egyptian mummy to be scientifically examined and given a medical diagnosis
title Tuberculosis in Dr Granville's mummy: a molecular re-examination of the earliest known Egyptian mummy to be scientifically examined and given a medical diagnosis
title_full Tuberculosis in Dr Granville's mummy: a molecular re-examination of the earliest known Egyptian mummy to be scientifically examined and given a medical diagnosis
title_fullStr Tuberculosis in Dr Granville's mummy: a molecular re-examination of the earliest known Egyptian mummy to be scientifically examined and given a medical diagnosis
title_full_unstemmed Tuberculosis in Dr Granville's mummy: a molecular re-examination of the earliest known Egyptian mummy to be scientifically examined and given a medical diagnosis
title_short Tuberculosis in Dr Granville's mummy: a molecular re-examination of the earliest known Egyptian mummy to be scientifically examined and given a medical diagnosis
title_sort tuberculosis in dr granville's mummy: a molecular re-examination of the earliest known egyptian mummy to be scientifically examined and given a medical diagnosis
topic Research articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2842630/
https://www.ncbi.nlm.nih.gov/pubmed/19793751
http://dx.doi.org/10.1098/rspb.2009.1484
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