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Cerebral Collateral Circulation in Carotid Artery Disease

Carotid artery disease is common and increases the risk of stroke. However, there is wide variability on the severity of clinical manifestations of carotid disease, ranging from asymptomatic to fatal stroke. The collateral circulation has been recognized as an important aspect of cerebral circulatio...

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Autores principales: Romero, José R, Pikula, Aleksandra, Nguyen, Thanh N, Nien, Yih Lin, Norbash, Alexander, Babikian, Viken L
Formato: Texto
Lenguaje:English
Publicado: Bentham Science Publishers Ltd. 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2842960/
https://www.ncbi.nlm.nih.gov/pubmed/21037845
http://dx.doi.org/10.2174/157340309789317887
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author Romero, José R
Pikula, Aleksandra
Nguyen, Thanh N
Nien, Yih Lin
Norbash, Alexander
Babikian, Viken L
author_facet Romero, José R
Pikula, Aleksandra
Nguyen, Thanh N
Nien, Yih Lin
Norbash, Alexander
Babikian, Viken L
author_sort Romero, José R
collection PubMed
description Carotid artery disease is common and increases the risk of stroke. However, there is wide variability on the severity of clinical manifestations of carotid disease, ranging from asymptomatic to fatal stroke. The collateral circulation has been recognized as an important aspect of cerebral circulation affecting the risk of stroke as well as other features of stroke presentation, such as stroke patterns in patients with carotid artery disease. The cerebral circulation attempts to maintain constant cerebral perfusion despite changes in systemic conditions, due to its ability to autoregulate blood flow. In case that one of the major cerebral arteries is compromised by occlusive disease, the cerebral collateral circulation plays an important role in preserving cerebral perfusion through enhanced recruitment of blood flow. With the advent of techniques that allow rapid evaluation of cerebral perfusion, the collateral circulation of the brain and its effectiveness may also be evaluated, allowing for prompt assessment of patients with acute stroke due to involvement of the carotid artery, and risk stratification of patients with carotid stenosis in chronic stages. Understanding the cerebral collateral circulation provides a basis for the future development of new diagnostic tools, risk stratification, predictive models and new therapeutic modalities. In the present review we discuss basic aspects of the cerebral collateral circulation, diagnostic methods to assess collateral circulation, and implications in occlusive carotid artery disease.
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spelling pubmed-28429602010-11-01 Cerebral Collateral Circulation in Carotid Artery Disease Romero, José R Pikula, Aleksandra Nguyen, Thanh N Nien, Yih Lin Norbash, Alexander Babikian, Viken L Curr Cardiol Rev Article Carotid artery disease is common and increases the risk of stroke. However, there is wide variability on the severity of clinical manifestations of carotid disease, ranging from asymptomatic to fatal stroke. The collateral circulation has been recognized as an important aspect of cerebral circulation affecting the risk of stroke as well as other features of stroke presentation, such as stroke patterns in patients with carotid artery disease. The cerebral circulation attempts to maintain constant cerebral perfusion despite changes in systemic conditions, due to its ability to autoregulate blood flow. In case that one of the major cerebral arteries is compromised by occlusive disease, the cerebral collateral circulation plays an important role in preserving cerebral perfusion through enhanced recruitment of blood flow. With the advent of techniques that allow rapid evaluation of cerebral perfusion, the collateral circulation of the brain and its effectiveness may also be evaluated, allowing for prompt assessment of patients with acute stroke due to involvement of the carotid artery, and risk stratification of patients with carotid stenosis in chronic stages. Understanding the cerebral collateral circulation provides a basis for the future development of new diagnostic tools, risk stratification, predictive models and new therapeutic modalities. In the present review we discuss basic aspects of the cerebral collateral circulation, diagnostic methods to assess collateral circulation, and implications in occlusive carotid artery disease. Bentham Science Publishers Ltd. 2009-11 /pmc/articles/PMC2842960/ /pubmed/21037845 http://dx.doi.org/10.2174/157340309789317887 Text en © 2009 Bentham Science Publishers Ltd. http://creativecommons.org/licenses/by/2.5/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/), which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Article
Romero, José R
Pikula, Aleksandra
Nguyen, Thanh N
Nien, Yih Lin
Norbash, Alexander
Babikian, Viken L
Cerebral Collateral Circulation in Carotid Artery Disease
title Cerebral Collateral Circulation in Carotid Artery Disease
title_full Cerebral Collateral Circulation in Carotid Artery Disease
title_fullStr Cerebral Collateral Circulation in Carotid Artery Disease
title_full_unstemmed Cerebral Collateral Circulation in Carotid Artery Disease
title_short Cerebral Collateral Circulation in Carotid Artery Disease
title_sort cerebral collateral circulation in carotid artery disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2842960/
https://www.ncbi.nlm.nih.gov/pubmed/21037845
http://dx.doi.org/10.2174/157340309789317887
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