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The Discovery of Novel Experimental Therapies for Inflammatory Arthritis
Conventional and biologic disease-modifying antirheumatic drugs have revolutionized the medical therapy of inflammatory arthritis. However, it remains unclear as to what can be done to treat immune-mediated chronic inflammation after patients become refractory to these therapies or develop serious s...
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Formato: | Texto |
Lenguaje: | English |
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Hindawi Publishing Corporation
2009
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2842969/ https://www.ncbi.nlm.nih.gov/pubmed/20339519 http://dx.doi.org/10.1155/2009/698769 |
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author | Malemud, Charles J. |
author_facet | Malemud, Charles J. |
author_sort | Malemud, Charles J. |
collection | PubMed |
description | Conventional and biologic disease-modifying antirheumatic drugs have revolutionized the medical therapy of inflammatory arthritis. However, it remains unclear as to what can be done to treat immune-mediated chronic inflammation after patients become refractory to these therapies or develop serious side-effects and/or infections forcing drug withdrawal. Because of these concerns it is imperative that novel targets be continuously identified and experimental strategies designed to test potential arthritis interventions in vitro, but more importantly, in well-validated animal models of inflammatory arthritis. Over the past few years, sphingosine-1-phosphate, interleukin-7 receptor, spleen tyrosine kinase, extracellular signal-regulated kinase, mitogen-activated protein kinase 5/p38 kinase regulated/activated protein kinase, micro-RNAs, tumor necrosis factor-related apoptosis inducing ligand and the polyubiquitin-proteasome pathway were identified as promising novel targets for potential antiarthritis drug development. Indeed several experimental compounds alter the biological activity of these targets and have shown clinical efficacy in animal models of arthritis. A few of them have even entered the first phase of human clinical trials. |
format | Text |
id | pubmed-2842969 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-28429692010-03-25 The Discovery of Novel Experimental Therapies for Inflammatory Arthritis Malemud, Charles J. Mediators Inflamm Review Article Conventional and biologic disease-modifying antirheumatic drugs have revolutionized the medical therapy of inflammatory arthritis. However, it remains unclear as to what can be done to treat immune-mediated chronic inflammation after patients become refractory to these therapies or develop serious side-effects and/or infections forcing drug withdrawal. Because of these concerns it is imperative that novel targets be continuously identified and experimental strategies designed to test potential arthritis interventions in vitro, but more importantly, in well-validated animal models of inflammatory arthritis. Over the past few years, sphingosine-1-phosphate, interleukin-7 receptor, spleen tyrosine kinase, extracellular signal-regulated kinase, mitogen-activated protein kinase 5/p38 kinase regulated/activated protein kinase, micro-RNAs, tumor necrosis factor-related apoptosis inducing ligand and the polyubiquitin-proteasome pathway were identified as promising novel targets for potential antiarthritis drug development. Indeed several experimental compounds alter the biological activity of these targets and have shown clinical efficacy in animal models of arthritis. A few of them have even entered the first phase of human clinical trials. Hindawi Publishing Corporation 2009 2010-02-18 /pmc/articles/PMC2842969/ /pubmed/20339519 http://dx.doi.org/10.1155/2009/698769 Text en Copyright © 2009 Charles J. Malemud. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Malemud, Charles J. The Discovery of Novel Experimental Therapies for Inflammatory Arthritis |
title | The Discovery of Novel Experimental Therapies for Inflammatory Arthritis |
title_full | The Discovery of Novel Experimental Therapies for Inflammatory Arthritis |
title_fullStr | The Discovery of Novel Experimental Therapies for Inflammatory Arthritis |
title_full_unstemmed | The Discovery of Novel Experimental Therapies for Inflammatory Arthritis |
title_short | The Discovery of Novel Experimental Therapies for Inflammatory Arthritis |
title_sort | discovery of novel experimental therapies for inflammatory arthritis |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2842969/ https://www.ncbi.nlm.nih.gov/pubmed/20339519 http://dx.doi.org/10.1155/2009/698769 |
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