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The Discovery of Novel Experimental Therapies for Inflammatory Arthritis

Conventional and biologic disease-modifying antirheumatic drugs have revolutionized the medical therapy of inflammatory arthritis. However, it remains unclear as to what can be done to treat immune-mediated chronic inflammation after patients become refractory to these therapies or develop serious s...

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Detalles Bibliográficos
Autor principal: Malemud, Charles J.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2842969/
https://www.ncbi.nlm.nih.gov/pubmed/20339519
http://dx.doi.org/10.1155/2009/698769
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author Malemud, Charles J.
author_facet Malemud, Charles J.
author_sort Malemud, Charles J.
collection PubMed
description Conventional and biologic disease-modifying antirheumatic drugs have revolutionized the medical therapy of inflammatory arthritis. However, it remains unclear as to what can be done to treat immune-mediated chronic inflammation after patients become refractory to these therapies or develop serious side-effects and/or infections forcing drug withdrawal. Because of these concerns it is imperative that novel targets be continuously identified and experimental strategies designed to test potential arthritis interventions in vitro, but more importantly, in well-validated animal models of inflammatory arthritis. Over the past few years, sphingosine-1-phosphate, interleukin-7 receptor, spleen tyrosine kinase, extracellular signal-regulated kinase, mitogen-activated protein kinase 5/p38 kinase regulated/activated protein kinase, micro-RNAs, tumor necrosis factor-related apoptosis inducing ligand and the polyubiquitin-proteasome pathway were identified as promising novel targets for potential antiarthritis drug development. Indeed several experimental compounds alter the biological activity of these targets and have shown clinical efficacy in animal models of arthritis. A few of them have even entered the first phase of human clinical trials.
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spelling pubmed-28429692010-03-25 The Discovery of Novel Experimental Therapies for Inflammatory Arthritis Malemud, Charles J. Mediators Inflamm Review Article Conventional and biologic disease-modifying antirheumatic drugs have revolutionized the medical therapy of inflammatory arthritis. However, it remains unclear as to what can be done to treat immune-mediated chronic inflammation after patients become refractory to these therapies or develop serious side-effects and/or infections forcing drug withdrawal. Because of these concerns it is imperative that novel targets be continuously identified and experimental strategies designed to test potential arthritis interventions in vitro, but more importantly, in well-validated animal models of inflammatory arthritis. Over the past few years, sphingosine-1-phosphate, interleukin-7 receptor, spleen tyrosine kinase, extracellular signal-regulated kinase, mitogen-activated protein kinase 5/p38 kinase regulated/activated protein kinase, micro-RNAs, tumor necrosis factor-related apoptosis inducing ligand and the polyubiquitin-proteasome pathway were identified as promising novel targets for potential antiarthritis drug development. Indeed several experimental compounds alter the biological activity of these targets and have shown clinical efficacy in animal models of arthritis. A few of them have even entered the first phase of human clinical trials. Hindawi Publishing Corporation 2009 2010-02-18 /pmc/articles/PMC2842969/ /pubmed/20339519 http://dx.doi.org/10.1155/2009/698769 Text en Copyright © 2009 Charles J. Malemud. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Malemud, Charles J.
The Discovery of Novel Experimental Therapies for Inflammatory Arthritis
title The Discovery of Novel Experimental Therapies for Inflammatory Arthritis
title_full The Discovery of Novel Experimental Therapies for Inflammatory Arthritis
title_fullStr The Discovery of Novel Experimental Therapies for Inflammatory Arthritis
title_full_unstemmed The Discovery of Novel Experimental Therapies for Inflammatory Arthritis
title_short The Discovery of Novel Experimental Therapies for Inflammatory Arthritis
title_sort discovery of novel experimental therapies for inflammatory arthritis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2842969/
https://www.ncbi.nlm.nih.gov/pubmed/20339519
http://dx.doi.org/10.1155/2009/698769
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