Response to Hydralazine-Valproate in a Patient with Mycosis Fungoides

Histone deacetylase (HDAC) inhibitors have shown significant activity in the treatment of cutaneous T-cell lymphomas (CTCL). The epigenetic alterations of CTCL not only are limited to altered histone acetylation but also include aberrant DNA gene methylation hence, the combination of an HDAC inhibit...

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Detalles Bibliográficos
Autores principales: Dueñas-Gonzalez, Alfonso, Vega, Maria Teresa, Martinez-Baños, Déborah, García-Hidalgo, Linda, Sobrevilla, Pedro
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2010
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2842973/
https://www.ncbi.nlm.nih.gov/pubmed/20339522
http://dx.doi.org/10.1155/2010/657579
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author Dueñas-Gonzalez, Alfonso
Vega, Maria Teresa
Martinez-Baños, Déborah
García-Hidalgo, Linda
Sobrevilla, Pedro
author_facet Dueñas-Gonzalez, Alfonso
Vega, Maria Teresa
Martinez-Baños, Déborah
García-Hidalgo, Linda
Sobrevilla, Pedro
author_sort Dueñas-Gonzalez, Alfonso
collection PubMed
description Histone deacetylase (HDAC) inhibitors have shown significant activity in the treatment of cutaneous T-cell lymphomas (CTCL). The epigenetic alterations of CTCL not only are limited to altered histone acetylation but also include aberrant DNA gene methylation hence, the combination of an HDAC inhibitor with a DNA demethylating agent is a promising therapy to be tested. Here we report a mycosis fungoides patient having a dramatic response to hydralazine and valproate, two repositioned drugs as HDAC and DNA methylation inhibitors, respectively.
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spelling pubmed-28429732010-03-25 Response to Hydralazine-Valproate in a Patient with Mycosis Fungoides Dueñas-Gonzalez, Alfonso Vega, Maria Teresa Martinez-Baños, Déborah García-Hidalgo, Linda Sobrevilla, Pedro Case Rep Med Case Report Histone deacetylase (HDAC) inhibitors have shown significant activity in the treatment of cutaneous T-cell lymphomas (CTCL). The epigenetic alterations of CTCL not only are limited to altered histone acetylation but also include aberrant DNA gene methylation hence, the combination of an HDAC inhibitor with a DNA demethylating agent is a promising therapy to be tested. Here we report a mycosis fungoides patient having a dramatic response to hydralazine and valproate, two repositioned drugs as HDAC and DNA methylation inhibitors, respectively. Hindawi Publishing Corporation 2010 2010-03-21 /pmc/articles/PMC2842973/ /pubmed/20339522 http://dx.doi.org/10.1155/2010/657579 Text en Copyright © 2010 Alfonso Dueñas-Gonzalez et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Dueñas-Gonzalez, Alfonso
Vega, Maria Teresa
Martinez-Baños, Déborah
García-Hidalgo, Linda
Sobrevilla, Pedro
Response to Hydralazine-Valproate in a Patient with Mycosis Fungoides
title Response to Hydralazine-Valproate in a Patient with Mycosis Fungoides
title_full Response to Hydralazine-Valproate in a Patient with Mycosis Fungoides
title_fullStr Response to Hydralazine-Valproate in a Patient with Mycosis Fungoides
title_full_unstemmed Response to Hydralazine-Valproate in a Patient with Mycosis Fungoides
title_short Response to Hydralazine-Valproate in a Patient with Mycosis Fungoides
title_sort response to hydralazine-valproate in a patient with mycosis fungoides
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2842973/
https://www.ncbi.nlm.nih.gov/pubmed/20339522
http://dx.doi.org/10.1155/2010/657579
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