IDN1 and IDN2: two proteins required for de novo DNA methylation in Arabidopsis thaliana

DNA methylation is an epigenetic mark affecting genes and transposons. We screened for mutations that fail to establish DNA methylation, yielding two mutants termed involved in de novo (idn). IDN1 encodes DMS3, an SMC related protein, IDN2 encodes a novel double stranded RNA binding protein with hom...

Descripción completa

Detalles Bibliográficos
Autores principales: Ausin, Israel, Mockler, Todd C., Chory, Joanne, Jacobsen, Steven E.
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2842998/
https://www.ncbi.nlm.nih.gov/pubmed/19915591
http://dx.doi.org/10.1038/nsmb.1690
Descripción
Sumario:DNA methylation is an epigenetic mark affecting genes and transposons. We screened for mutations that fail to establish DNA methylation, yielding two mutants termed involved in de novo (idn). IDN1 encodes DMS3, an SMC related protein, IDN2 encodes a novel double stranded RNA binding protein with homology to SGS3. IDN1 and IDN2 control de novo methylation and siRNA-mediated maintenance methylation and are components of the RNA-directed DNA methylation pathway.

Ejemplares similares