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Src Kinase Phosphorylates RUNX3 at Tyrosine Residues and Localizes the Protein in the Cytoplasm
RUNX3 is a transcription factor that functions as a tumor suppressor. In some cancers, RUNX3 expression is down-regulated, usually due to promoter hypermethylation. Recently, it was found that RUNX3 can also be inactivated by the mislocalization of the protein in the cytoplasm. The molecular mechani...
Autores principales: | Goh, Yun-Mi, Cinghu, Senthilkumar, Hong, Eileen Tan Hwee, Lee, You-Soub, Kim, Jang-Hyun, Jang, Ju-Won, Li, Ying-Hui, Chi, Xin-Zi, Lee, Kyeong-Sook, Wee, Heejun, Ito, Yoshiaki, Oh, Byung-Chul, Bae, Suk-Chul |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
American Society for Biochemistry and Molecular Biology
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2843174/ https://www.ncbi.nlm.nih.gov/pubmed/20100835 http://dx.doi.org/10.1074/jbc.M109.071381 |
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