Pituitary Adenylate Cyclase-activating Polypeptide (PACAP)/PAC(1)HOP1 Receptor Activation Coordinates Multiple Neurotrophic Signaling Pathways: Akt ACTIVATION THROUGH PHOSPHATIDYLINOSITOL 3-KINASE γ AND VESICLE ENDOCYTOSIS FOR NEURONAL SURVIVAL

MAPK and Akt pathways are predominant mediators of trophic signaling for many neuronal systems. Among the vasoactive intestinal peptide/secretin/glucagon family of related peptides, pituitary adenylate cyclase-activating polypeptide (PACAP) binding to specific PAC(1) receptor isoforms can engage mul...

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Detalles Bibliográficos
Autores principales: May, Victor, Lutz, Eve, MacKenzie, Christopher, Schutz, Kristin C., Dozark, Kate, Braas, Karen M.
Formato: Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2010
Materias:
Neurobiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2843224/
https://www.ncbi.nlm.nih.gov/pubmed/20093365
http://dx.doi.org/10.1074/jbc.M109.043117

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