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Promoter methylation analysis of O6-methylguanine-DNA methyltransferase in glioblastoma: detection by locked nucleic acid based quantitative PCR using an imprinted gene (SNURF) as a reference

BACKGROUND: Epigenetic silencing of the MGMT gene by promoter methylation is associated with loss of MGMT expression, diminished DNA-repair activity and longer overall survival in patients with glioblastoma who, in addition to radiotherapy, received alkylating chemotherapy with carmustine or temozol...

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Detalles Bibliográficos
Autores principales:	Morandi, Luca, Franceschi, Enrico, de Biase, Dario, Marucci, Gianluca, Tosoni, Alicia, Ermani, Mario, Pession, Annalisa, Tallini, Giovanni, Brandes, Alba
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2010
Materias:	Technical Advance
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2843669/ https://www.ncbi.nlm.nih.gov/pubmed/20167086 http://dx.doi.org/10.1186/1471-2407-10-48

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