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Characterization of Recombinant Dengue-2 Virus Derived from a Single Nucleotide Substitution in the 5′ Noncoding Region

Variants of wild-type dengue serotype 2 (DEN-2) virus containing nucleotide substitutions at positions 14, 15, or 57 in the 5′ NCR were constructed by PCR-mediated site-directed mutagenesis. All three viruses containing a single point substitution demonstrated attenuation phenotype as evidenced by d...

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Detalles Bibliográficos
Autores principales:	Leardkamolkarn, Vijittra, Sirigulpanit, Wipawan, Kinney, Richard M.
Formato:	Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2843905/ https://www.ncbi.nlm.nih.gov/pubmed/20339476 http://dx.doi.org/10.1155/2010/934694

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