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Phospholipid-esterified Eicosanoids Are Generated in Agonist-activated Human Platelets and Enhance Tissue Factor-dependent Thrombin Generation

Here, a group of specific lipids, comprising phosphatidylethanolamine (PE)- or phosphatidylcholine (PC)-esterified 12S-hydroxyeicosatetraenoic acid (12S-HETE), generated by 12-lipoxygenase was identified and characterized. 12S-HETE-PE/PCs were formed within 5 min of activation by thrombin, ionophore...

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Detalles Bibliográficos
Autores principales:	Thomas, Christopher P., Morgan, Lloyd T., Maskrey, Benjamin H., Murphy, Robert C., Kühn, Hartmut, Hazen, Stanley L., Goodall, Alison H., Hamali, Hassan A., Collins, Peter W., O'Donnell, Valerie B.
Formato:	Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2010
Materias:	Lipids
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2844139/ https://www.ncbi.nlm.nih.gov/pubmed/20061396 http://dx.doi.org/10.1074/jbc.M109.078428

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