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Mycobacterium tuberculosis cAMP Receptor Protein (Rv3676) Differs from the Escherichia coli Paradigm in Its cAMP Binding and DNA Binding Properties and Transcription Activation Properties

The pathogen Mycobacterium tuberculosis produces a burst of cAMP upon infection of macrophages. Bacterial cyclic AMP receptor proteins (CRP) are transcription factors that respond to cAMP by binding at target promoters when cAMP concentrations increase. Rv3676 (CRP(Mt)) is a CRP family protein that...

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Detalles Bibliográficos
Autores principales:	Stapleton, Melanie, Haq, Ihtshamul, Hunt, Debbie M., Arnvig, Kristine B., Artymiuk, Peter J., Buxton, Roger S., Green, Jeffrey
Formato:	Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2010
Materias:	Gene Regulation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2844151/ https://www.ncbi.nlm.nih.gov/pubmed/20028978 http://dx.doi.org/10.1074/jbc.M109.047720

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