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Growth restriction of an experimental live attenuated human parainfluenza virus type 2 vaccine in human ciliated airway epithelium in vitro parallels attenuation in African green monkeys

Human parainfluenza viruses (HPIVs) are common causes of severe pediatric respiratory viral disease. We characterized wild-type HPIV2 infection in an in vitro model of human airway epithelium (HAE) and found that the virus replicates to high titer, sheds apically, targets ciliated cells, and induces...

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Detalles Bibliográficos
Autores principales:	Schaap-Nutt, Anne, Scull, Margaret A., Schmidt, Alexander C., Murphy, Brian R., Pickles, Raymond J.
Formato:	Texto
Lenguaje:	English
Publicado:	Elsevier Ltd. Published by Elsevier Ltd. 2010
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2844349/ https://www.ncbi.nlm.nih.gov/pubmed/20139039 http://dx.doi.org/10.1016/j.vaccine.2010.01.050

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