Mutation or loss of Wilms' tumor gene 1 (WT1) are not major reasons for immune escape in patients with AML receiving WT1 peptide vaccination

BACKGROUND: Efficacy of cancer vaccines may be limited due to immune escape mechanisms like loss or mutation of target antigens. Here, we analyzed 10 HLA-A2 positive patients with acute myeloid leukemia (AML) for loss or mutations of the WT1 epitope or epitope flanking sequences that may abolish pro...

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Detalles Bibliográficos
Autores principales: Busse, Antonia, Letsch, Anne, Scheibenbogen, Carmen, Nonnenmacher, Anika, Ochsenreither, Sebastian, Thiel, Eckhard, Keilholz, Ulrich
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2844374/
https://www.ncbi.nlm.nih.gov/pubmed/20092642
http://dx.doi.org/10.1186/1479-5876-8-5

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