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Infections after Living Donor Liver Transplantation in Children
The aim of this study was to evaluate the infectious complications after living donor liver transplantation (LDLT) in children. We enrolled 95 children (38 boys and 57 girls) who underwent LDLT from 1994 to 2004. The median age was 22 months (range, 6 months to 15 yr). We retrospectively investigate...
Autores principales: | , , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Korean Academy of Medical Sciences
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2844587/ https://www.ncbi.nlm.nih.gov/pubmed/20357992 http://dx.doi.org/10.3346/jkms.2010.25.4.527 |
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author | Kim, Jeong Eun Oh, Seak Hee Kim, Kyung Mo Choi, Bo Hwa Kim, Dae Yeon Cho, Hyung Rae Lee, Yeoun Joo Rhee, Kang Won Park, Seong Jong Lee, Young Joo Lee, Sung Gyu |
author_facet | Kim, Jeong Eun Oh, Seak Hee Kim, Kyung Mo Choi, Bo Hwa Kim, Dae Yeon Cho, Hyung Rae Lee, Yeoun Joo Rhee, Kang Won Park, Seong Jong Lee, Young Joo Lee, Sung Gyu |
author_sort | Kim, Jeong Eun |
collection | PubMed |
description | The aim of this study was to evaluate the infectious complications after living donor liver transplantation (LDLT) in children. We enrolled 95 children (38 boys and 57 girls) who underwent LDLT from 1994 to 2004. The median age was 22 months (range, 6 months to 15 yr). We retrospectively investigated the proven episodes of bacterial, viral, and fungal infection. There occurred 150 infections in 67 (70%) of 95 patients (1.49 infections/patient); 74 in 43 patients were bacterial, 2 in 2 were fungal, and 74 in 42 were viral. The most common sites of bacterial infection were the bloodstream (33%) and abdomen (25%). Most of the bacterial infections occurred within the first month after LDLT. Bacterial and fungal infections did not result in any deaths. The most common causes of viral infection were Epstein-Barr virus in 37 patients and cytomegalovirus in 18. Seven of the 14 deaths after LDLT were associated with viral infection. Our study suggests that infection is one of the important causes of morbidity and mortality after LDLT. Especially careful monitoring and management of viral infections is crucial for improving the outcome of LDLT in children. |
format | Text |
id | pubmed-2844587 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | The Korean Academy of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-28445872010-04-01 Infections after Living Donor Liver Transplantation in Children Kim, Jeong Eun Oh, Seak Hee Kim, Kyung Mo Choi, Bo Hwa Kim, Dae Yeon Cho, Hyung Rae Lee, Yeoun Joo Rhee, Kang Won Park, Seong Jong Lee, Young Joo Lee, Sung Gyu J Korean Med Sci Original Article The aim of this study was to evaluate the infectious complications after living donor liver transplantation (LDLT) in children. We enrolled 95 children (38 boys and 57 girls) who underwent LDLT from 1994 to 2004. The median age was 22 months (range, 6 months to 15 yr). We retrospectively investigated the proven episodes of bacterial, viral, and fungal infection. There occurred 150 infections in 67 (70%) of 95 patients (1.49 infections/patient); 74 in 43 patients were bacterial, 2 in 2 were fungal, and 74 in 42 were viral. The most common sites of bacterial infection were the bloodstream (33%) and abdomen (25%). Most of the bacterial infections occurred within the first month after LDLT. Bacterial and fungal infections did not result in any deaths. The most common causes of viral infection were Epstein-Barr virus in 37 patients and cytomegalovirus in 18. Seven of the 14 deaths after LDLT were associated with viral infection. Our study suggests that infection is one of the important causes of morbidity and mortality after LDLT. Especially careful monitoring and management of viral infections is crucial for improving the outcome of LDLT in children. The Korean Academy of Medical Sciences 2010-04 2010-03-19 /pmc/articles/PMC2844587/ /pubmed/20357992 http://dx.doi.org/10.3346/jkms.2010.25.4.527 Text en © 2010 The Korean Academy of Medical Sciences. http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Kim, Jeong Eun Oh, Seak Hee Kim, Kyung Mo Choi, Bo Hwa Kim, Dae Yeon Cho, Hyung Rae Lee, Yeoun Joo Rhee, Kang Won Park, Seong Jong Lee, Young Joo Lee, Sung Gyu Infections after Living Donor Liver Transplantation in Children |
title | Infections after Living Donor Liver Transplantation in Children |
title_full | Infections after Living Donor Liver Transplantation in Children |
title_fullStr | Infections after Living Donor Liver Transplantation in Children |
title_full_unstemmed | Infections after Living Donor Liver Transplantation in Children |
title_short | Infections after Living Donor Liver Transplantation in Children |
title_sort | infections after living donor liver transplantation in children |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2844587/ https://www.ncbi.nlm.nih.gov/pubmed/20357992 http://dx.doi.org/10.3346/jkms.2010.25.4.527 |
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