Recurrence of Type 1 Diabetes After Simultaneous Pancreas-Kidney Transplantation, Despite Immunosuppression, Is Associated With Autoantibodies and Pathogenic Autoreactive CD4 T-Cells

OBJECTIVE: To investigate if recurrent autoimmunity explained hyperglycemia and C-peptide loss in three immunosuppressed simultaneous pancreas-kidney (SPK) transplant recipients. RESEARCH DESIGN AND METHODS: We monitored autoantibodies and autoreactive T-cells (using tetramers) and performed biopsy....

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Detalles Bibliográficos
Autores principales: Vendrame, Francesco, Pileggi, Antonello, Laughlin, Elsa, Allende, Gloria, Martin-Pagola, Ainhoa, Molano, R. Damaris, Diamantopoulos, Stavros, Standifer, Nathan, Geubtner, Kelly, Falk, Ben A., Ichii, Hirohito, Takahashi, Hidenori, Snowhite, Isaac, Chen, Zhibin, Mendez, Armando, Chen, Linda, Sageshima, Junichiro, Ruiz, Phillip, Ciancio, Gaetano, Ricordi, Camillo, Reijonen, Helena, Nepom, Gerald T., Burke, George W., Pugliese, Alberto
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2010
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2844842/
https://www.ncbi.nlm.nih.gov/pubmed/20086230
http://dx.doi.org/10.2337/db09-0498

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