Conserved regulatory motifs at phenylethanolamine N-methyltransferase (PNMT) are disrupted by common functional genetic variation: an integrated computational/experimental approach

The adrenomedullary hormone epinephrine transduces environmental stressors into cardiovascular events (tachycardia and hypertension). Although the epinephrine biosynthetic enzyme PNMT genetic locus displays both linkage and association to such traits, genetic variation underlying these quantitative...

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Detalles Bibliográficos
Autores principales: Rodríguez-Flores, Juan L., Zhang, Kuixing, Kang, Sun Woo, Wen, Gen, Ghosh, Sajalendu, Friese, Ryan S., Mahata, Sushil K., Subramaniam, Shankar, Hamilton, Bruce A., O’Connor, Daniel T.
Formato: Texto
Lenguaje:English
Publicado: Springer-Verlag 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2844968/
https://www.ncbi.nlm.nih.gov/pubmed/20204374
http://dx.doi.org/10.1007/s00335-010-9253-y

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