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Role of Adiposity and Lifestyle in the Relationship Between Family History of Diabetes and 20-Year Incidence of Type 2 Diabetes in U.S. Women
OBJECTIVE: To evaluate to what extent the association between family history of diabetes and risk of type 2 diabetes can be explained by excess adiposity and lifestyle risk factors. RESEARCH DESIGN AND METHODS: We analyzed data from 73,227 women who participated in the Nurses' Health Study coho...
Autores principales: | , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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American Diabetes Association
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2845024/ https://www.ncbi.nlm.nih.gov/pubmed/20067970 http://dx.doi.org/10.2337/dc09-1586 |
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author | van 't Riet, Esther Dekker, Jacqueline M. Sun, Qi Nijpels, Giel Hu, Frank B. van Dam, Rob M. |
author_facet | van 't Riet, Esther Dekker, Jacqueline M. Sun, Qi Nijpels, Giel Hu, Frank B. van Dam, Rob M. |
author_sort | van 't Riet, Esther |
collection | PubMed |
description | OBJECTIVE: To evaluate to what extent the association between family history of diabetes and risk of type 2 diabetes can be explained by excess adiposity and lifestyle risk factors. RESEARCH DESIGN AND METHODS: We analyzed data from 73,227 women who participated in the Nurses' Health Study cohort. A family history of diabetes was defined as having at least one first-degree family member with diabetes. Lifestyle factors, weight, and height were assessed by using validated questionnaires, and BMI was calculated. The relative risk of type 2 diabetes was estimated using Cox proportional hazards analysis. RESULTS: We documented 5,101 cases of type 2 diabetes during 20 years of follow-up. The age-adjusted relative risk of type 2 diabetes in participants with a family history was 2.27 (95% CI 2.14–2.40) compared with the risk in those without a family history of diabetes. Participants with a family history of diabetes had a higher BMI and were more likely to have a parental history of obesity. BMI explained 21.1% (19.4–22.9) of the association between family history of diabetes and risk of type 2 diabetes. Intakes of red meat, alcohol, and sugar-sweetened beverages explained 1.1% (0.8–1.3), 4.8% (4.3–5.3), and 2.8% (2.4–3.2) of this association, respectively. CONCLUSIONS: These results suggest that excess adiposity and, to a lesser extent, specific dietary habits can explain a substantial part of the association between having a family history of diabetes and risk of type 2 diabetes. |
format | Text |
id | pubmed-2845024 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | American Diabetes Association |
record_format | MEDLINE/PubMed |
spelling | pubmed-28450242011-04-01 Role of Adiposity and Lifestyle in the Relationship Between Family History of Diabetes and 20-Year Incidence of Type 2 Diabetes in U.S. Women van 't Riet, Esther Dekker, Jacqueline M. Sun, Qi Nijpels, Giel Hu, Frank B. van Dam, Rob M. Diabetes Care Original Research OBJECTIVE: To evaluate to what extent the association between family history of diabetes and risk of type 2 diabetes can be explained by excess adiposity and lifestyle risk factors. RESEARCH DESIGN AND METHODS: We analyzed data from 73,227 women who participated in the Nurses' Health Study cohort. A family history of diabetes was defined as having at least one first-degree family member with diabetes. Lifestyle factors, weight, and height were assessed by using validated questionnaires, and BMI was calculated. The relative risk of type 2 diabetes was estimated using Cox proportional hazards analysis. RESULTS: We documented 5,101 cases of type 2 diabetes during 20 years of follow-up. The age-adjusted relative risk of type 2 diabetes in participants with a family history was 2.27 (95% CI 2.14–2.40) compared with the risk in those without a family history of diabetes. Participants with a family history of diabetes had a higher BMI and were more likely to have a parental history of obesity. BMI explained 21.1% (19.4–22.9) of the association between family history of diabetes and risk of type 2 diabetes. Intakes of red meat, alcohol, and sugar-sweetened beverages explained 1.1% (0.8–1.3), 4.8% (4.3–5.3), and 2.8% (2.4–3.2) of this association, respectively. CONCLUSIONS: These results suggest that excess adiposity and, to a lesser extent, specific dietary habits can explain a substantial part of the association between having a family history of diabetes and risk of type 2 diabetes. American Diabetes Association 2010-04 2010-01-12 /pmc/articles/PMC2845024/ /pubmed/20067970 http://dx.doi.org/10.2337/dc09-1586 Text en © 2010 by the American Diabetes Association. https://creativecommons.org/licenses/by-nc-nd/3.0/Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ (https://creativecommons.org/licenses/by-nc-nd/3.0/) for details. |
spellingShingle | Original Research van 't Riet, Esther Dekker, Jacqueline M. Sun, Qi Nijpels, Giel Hu, Frank B. van Dam, Rob M. Role of Adiposity and Lifestyle in the Relationship Between Family History of Diabetes and 20-Year Incidence of Type 2 Diabetes in U.S. Women |
title | Role of Adiposity and Lifestyle in the Relationship Between Family History of Diabetes and 20-Year Incidence of Type 2 Diabetes in U.S. Women |
title_full | Role of Adiposity and Lifestyle in the Relationship Between Family History of Diabetes and 20-Year Incidence of Type 2 Diabetes in U.S. Women |
title_fullStr | Role of Adiposity and Lifestyle in the Relationship Between Family History of Diabetes and 20-Year Incidence of Type 2 Diabetes in U.S. Women |
title_full_unstemmed | Role of Adiposity and Lifestyle in the Relationship Between Family History of Diabetes and 20-Year Incidence of Type 2 Diabetes in U.S. Women |
title_short | Role of Adiposity and Lifestyle in the Relationship Between Family History of Diabetes and 20-Year Incidence of Type 2 Diabetes in U.S. Women |
title_sort | role of adiposity and lifestyle in the relationship between family history of diabetes and 20-year incidence of type 2 diabetes in u.s. women |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2845024/ https://www.ncbi.nlm.nih.gov/pubmed/20067970 http://dx.doi.org/10.2337/dc09-1586 |
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