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High Levels of Foot Ulceration and Amputation Risk in a Multiracial Cohort of Diabetic Patients on Dialysis Therapy
OBJECTIVE: To evaluate the prevalence of lower-limb complications in a multiracial cohort of patients with diabetes receiving dialysis. RESEARCH DESIGN AND METHODS: This work was a cross-sectional study of lower-limb complications in dialysis-treated patients with diabetes in the U.K. and U.S. RESUL...
Autores principales: | , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
American Diabetes Association
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2845045/ https://www.ncbi.nlm.nih.gov/pubmed/20067975 http://dx.doi.org/10.2337/dc09-2007 |
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author | Ndip, Agbor Lavery, Lawrence A. LaFontaine, Javier Rutter, Martin K. Vardhan, Anand Vileikyte, Loretta Boulton, Andrew J.M. |
author_facet | Ndip, Agbor Lavery, Lawrence A. LaFontaine, Javier Rutter, Martin K. Vardhan, Anand Vileikyte, Loretta Boulton, Andrew J.M. |
author_sort | Ndip, Agbor |
collection | PubMed |
description | OBJECTIVE: To evaluate the prevalence of lower-limb complications in a multiracial cohort of patients with diabetes receiving dialysis. RESEARCH DESIGN AND METHODS: This work was a cross-sectional study of lower-limb complications in dialysis-treated patients with diabetes in the U.K. and U.S. RESULTS: We studied 466 patients (139 U.K.; 327 U.S.). The prevalence of lower-limb complications was high (foot ulcers 12%, neuropathy 79%, peripheral arterial disease 57%, history of foot ulceration 34%, and prior amputation 18%), with no significant ethnic variation, except that foot ulcers were more common in whites than in patients of African descent (P = 0.013). Ninety-five percent of patients were at high risk of lower-limb complications. Prior amputation was related to foot ulcer history, peripheral arterial disease, and hemodialysis modality in multivariable analysis. Prevalent ulceration showed independent associations with foot ulcer history and peripheral arterial disease, but not with ethnicity. CONCLUSIONS: All patients with diabetes receiving dialysis are at high risk of lower-limb complications independent of ethnic background. |
format | Text |
id | pubmed-2845045 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | American Diabetes Association |
record_format | MEDLINE/PubMed |
spelling | pubmed-28450452011-04-01 High Levels of Foot Ulceration and Amputation Risk in a Multiracial Cohort of Diabetic Patients on Dialysis Therapy Ndip, Agbor Lavery, Lawrence A. LaFontaine, Javier Rutter, Martin K. Vardhan, Anand Vileikyte, Loretta Boulton, Andrew J.M. Diabetes Care Original Research OBJECTIVE: To evaluate the prevalence of lower-limb complications in a multiracial cohort of patients with diabetes receiving dialysis. RESEARCH DESIGN AND METHODS: This work was a cross-sectional study of lower-limb complications in dialysis-treated patients with diabetes in the U.K. and U.S. RESULTS: We studied 466 patients (139 U.K.; 327 U.S.). The prevalence of lower-limb complications was high (foot ulcers 12%, neuropathy 79%, peripheral arterial disease 57%, history of foot ulceration 34%, and prior amputation 18%), with no significant ethnic variation, except that foot ulcers were more common in whites than in patients of African descent (P = 0.013). Ninety-five percent of patients were at high risk of lower-limb complications. Prior amputation was related to foot ulcer history, peripheral arterial disease, and hemodialysis modality in multivariable analysis. Prevalent ulceration showed independent associations with foot ulcer history and peripheral arterial disease, but not with ethnicity. CONCLUSIONS: All patients with diabetes receiving dialysis are at high risk of lower-limb complications independent of ethnic background. American Diabetes Association 2010-04 2010-01-12 /pmc/articles/PMC2845045/ /pubmed/20067975 http://dx.doi.org/10.2337/dc09-2007 Text en © 2010 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details. |
spellingShingle | Original Research Ndip, Agbor Lavery, Lawrence A. LaFontaine, Javier Rutter, Martin K. Vardhan, Anand Vileikyte, Loretta Boulton, Andrew J.M. High Levels of Foot Ulceration and Amputation Risk in a Multiracial Cohort of Diabetic Patients on Dialysis Therapy |
title | High Levels of Foot Ulceration and Amputation Risk in a Multiracial Cohort of Diabetic Patients on Dialysis Therapy |
title_full | High Levels of Foot Ulceration and Amputation Risk in a Multiracial Cohort of Diabetic Patients on Dialysis Therapy |
title_fullStr | High Levels of Foot Ulceration and Amputation Risk in a Multiracial Cohort of Diabetic Patients on Dialysis Therapy |
title_full_unstemmed | High Levels of Foot Ulceration and Amputation Risk in a Multiracial Cohort of Diabetic Patients on Dialysis Therapy |
title_short | High Levels of Foot Ulceration and Amputation Risk in a Multiracial Cohort of Diabetic Patients on Dialysis Therapy |
title_sort | high levels of foot ulceration and amputation risk in a multiracial cohort of diabetic patients on dialysis therapy |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2845045/ https://www.ncbi.nlm.nih.gov/pubmed/20067975 http://dx.doi.org/10.2337/dc09-2007 |
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