ERO1-β, a pancreas-specific disulfide oxidase, promotes insulin biogenesis and glucose homeostasis

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Mammals have two genes encoding homologues of the endoplasmic reticulum (ER) disulfide oxidase ERO1 (ER oxidoreductin 1). ERO1-β is greatly enriched in the endocrine pancreas. We report in this study that homozygosity for a disrupting allele of Ero1lb selectively compromises oxidative folding of pro...

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Detalles Bibliográficos
Autores principales: Zito, Ester, Chin, King-Tung, Blais, Jaime, Harding, Heather P., Ron, David
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2010
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2845084/
https://www.ncbi.nlm.nih.gov/pubmed/20308425
http://dx.doi.org/10.1083/jcb.200911086
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