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Structural insights into RNA Processing by the Human RISC-Loading Complex

Targeted gene silencing by RNA interference (RNAi) requires loading of a short guide RNA (siRNA or miRNA) into an Argonaute protein to form the functional center of an RNA-induced silencing complex (RISC). In humans, Argonaute2 (Ago2) assembles with the guide RNA-generating enzyme Dicer and the RNA-...

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Detalles Bibliográficos
Autores principales:	Wang, Hong-Wei, Noland, Cameron, Siridechadilok, Bunpote, Taylor, David W., Ma, Enbo, Felderer, Karin, Doudna, Jennifer A., Nogales, Eva
Formato:	Texto
Lenguaje:	English
Publicado:	2009
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2845538/ https://www.ncbi.nlm.nih.gov/pubmed/19820710 http://dx.doi.org/10.1038/nsmb.1673

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