miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis

MicroRNAs (miRNAs) are increasingly implicated in regulating the malignant progression of cancer. Here we show that miR-9, the level of which is upregulated in breast cancer cells, directly targets CDH1, the E-cadherin-encoding mRNA, leading to increased cell motility and invasiveness. miR-9-mediate...

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Detalles Bibliográficos
Autores principales: Ma, Li, Young, Jennifer, Prabhala, Harsha, Pan, Elizabeth, Mestdagh, Pieter, Muth, Daniel, Teruya-Feldstein, Julie, Reinhardt, Ferenc, Onder, Tamer T., Valastyan, Scott, Westermann, Frank, Speleman, Frank, Vandesompele, Jo, Weinberg, Robert A.
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2845545/
https://www.ncbi.nlm.nih.gov/pubmed/20173740
http://dx.doi.org/10.1038/ncb2024

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