Cargando…

Improvement of myocardial perfusion reserve detected by cardiovascular magnetic resonance after direct endomyocardial implantation of autologous bone marrow cells in patients with severe coronary artery disease

BACKGROUND: Recent studies suggested that bone marrow (BM) cell implantation in patients with severe chronic coronary artery disease (CAD) resulted in modest improvement in symptoms and cardiac function. This study sought to investigate the functional changes that occur within the chronic human isch...

Descripción completa

Detalles Bibliográficos
Autores principales: Chan, Carmen Wing-Sze, Kwong, Yok-Lam, Kwong, Raymond Y, Lau, Chu-Pak, Tse, Hung-Fat
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2845579/
https://www.ncbi.nlm.nih.gov/pubmed/20100336
http://dx.doi.org/10.1186/1532-429X-12-6
_version_ 1782179411203719168
author Chan, Carmen Wing-Sze
Kwong, Yok-Lam
Kwong, Raymond Y
Lau, Chu-Pak
Tse, Hung-Fat
author_facet Chan, Carmen Wing-Sze
Kwong, Yok-Lam
Kwong, Raymond Y
Lau, Chu-Pak
Tse, Hung-Fat
author_sort Chan, Carmen Wing-Sze
collection PubMed
description BACKGROUND: Recent studies suggested that bone marrow (BM) cell implantation in patients with severe chronic coronary artery disease (CAD) resulted in modest improvement in symptoms and cardiac function. This study sought to investigate the functional changes that occur within the chronic human ischaemic myocardium after direct endomyocardial BM cells implantation by cardiovascular magnetic resonance (CMR). METHODS AND RESULTS: We compared the interval changes of left ventricular ejection fraction (LVEF), myocardial perfusion reserve and the extent of myocardial scar by using late gadolinium enhancement CMR in 12 patients with severe CAD. CMR was performed at baseline and at 6 months after catheter-based direct endomyocardial autologous BM cell (n = 12) injection to viable ischaemic myocardium as guided by electromechanical mapping. In patients randomized to receive BM cell injection, there was significant decrease in percentage area of peri-infarct regions (-23.6%, P = 0.04) and increase in global LVEF (+9.0%, P = 0.02), the percentage of regional wall thickening (+13.1%, P= 0.04) and MPR (+0.25%, P = 0.03) over the target area at 6-months compared with baseline. CONCLUSIONS: Direct endomyocardial implantation of autologous BM cells significantly improved global LVEF, regional wall thickening and myocardial perfusion reserve, and reduced percentage area of peri-infarct regions in patients with severe CAD.
format Text
id pubmed-2845579
institution National Center for Biotechnology Information
language English
publishDate 2010
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-28455792010-03-26 Improvement of myocardial perfusion reserve detected by cardiovascular magnetic resonance after direct endomyocardial implantation of autologous bone marrow cells in patients with severe coronary artery disease Chan, Carmen Wing-Sze Kwong, Yok-Lam Kwong, Raymond Y Lau, Chu-Pak Tse, Hung-Fat J Cardiovasc Magn Reson Research BACKGROUND: Recent studies suggested that bone marrow (BM) cell implantation in patients with severe chronic coronary artery disease (CAD) resulted in modest improvement in symptoms and cardiac function. This study sought to investigate the functional changes that occur within the chronic human ischaemic myocardium after direct endomyocardial BM cells implantation by cardiovascular magnetic resonance (CMR). METHODS AND RESULTS: We compared the interval changes of left ventricular ejection fraction (LVEF), myocardial perfusion reserve and the extent of myocardial scar by using late gadolinium enhancement CMR in 12 patients with severe CAD. CMR was performed at baseline and at 6 months after catheter-based direct endomyocardial autologous BM cell (n = 12) injection to viable ischaemic myocardium as guided by electromechanical mapping. In patients randomized to receive BM cell injection, there was significant decrease in percentage area of peri-infarct regions (-23.6%, P = 0.04) and increase in global LVEF (+9.0%, P = 0.02), the percentage of regional wall thickening (+13.1%, P= 0.04) and MPR (+0.25%, P = 0.03) over the target area at 6-months compared with baseline. CONCLUSIONS: Direct endomyocardial implantation of autologous BM cells significantly improved global LVEF, regional wall thickening and myocardial perfusion reserve, and reduced percentage area of peri-infarct regions in patients with severe CAD. BioMed Central 2010-01-25 /pmc/articles/PMC2845579/ /pubmed/20100336 http://dx.doi.org/10.1186/1532-429X-12-6 Text en Copyright ©2010 Chan et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Chan, Carmen Wing-Sze
Kwong, Yok-Lam
Kwong, Raymond Y
Lau, Chu-Pak
Tse, Hung-Fat
Improvement of myocardial perfusion reserve detected by cardiovascular magnetic resonance after direct endomyocardial implantation of autologous bone marrow cells in patients with severe coronary artery disease
title Improvement of myocardial perfusion reserve detected by cardiovascular magnetic resonance after direct endomyocardial implantation of autologous bone marrow cells in patients with severe coronary artery disease
title_full Improvement of myocardial perfusion reserve detected by cardiovascular magnetic resonance after direct endomyocardial implantation of autologous bone marrow cells in patients with severe coronary artery disease
title_fullStr Improvement of myocardial perfusion reserve detected by cardiovascular magnetic resonance after direct endomyocardial implantation of autologous bone marrow cells in patients with severe coronary artery disease
title_full_unstemmed Improvement of myocardial perfusion reserve detected by cardiovascular magnetic resonance after direct endomyocardial implantation of autologous bone marrow cells in patients with severe coronary artery disease
title_short Improvement of myocardial perfusion reserve detected by cardiovascular magnetic resonance after direct endomyocardial implantation of autologous bone marrow cells in patients with severe coronary artery disease
title_sort improvement of myocardial perfusion reserve detected by cardiovascular magnetic resonance after direct endomyocardial implantation of autologous bone marrow cells in patients with severe coronary artery disease
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2845579/
https://www.ncbi.nlm.nih.gov/pubmed/20100336
http://dx.doi.org/10.1186/1532-429X-12-6
work_keys_str_mv AT chancarmenwingsze improvementofmyocardialperfusionreservedetectedbycardiovascularmagneticresonanceafterdirectendomyocardialimplantationofautologousbonemarrowcellsinpatientswithseverecoronaryarterydisease
AT kwongyoklam improvementofmyocardialperfusionreservedetectedbycardiovascularmagneticresonanceafterdirectendomyocardialimplantationofautologousbonemarrowcellsinpatientswithseverecoronaryarterydisease
AT kwongraymondy improvementofmyocardialperfusionreservedetectedbycardiovascularmagneticresonanceafterdirectendomyocardialimplantationofautologousbonemarrowcellsinpatientswithseverecoronaryarterydisease
AT lauchupak improvementofmyocardialperfusionreservedetectedbycardiovascularmagneticresonanceafterdirectendomyocardialimplantationofautologousbonemarrowcellsinpatientswithseverecoronaryarterydisease
AT tsehungfat improvementofmyocardialperfusionreservedetectedbycardiovascularmagneticresonanceafterdirectendomyocardialimplantationofautologousbonemarrowcellsinpatientswithseverecoronaryarterydisease