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Physical Association of PDK1 with AKT1 Is Sufficient for Pathway Activation Independent of Membrane Localization and Phosphatidylinositol 3 Kinase

Frequent activation of the AKT serine-threonine kinase in cancer confers resistance to therapy. AKT is activated by a multi-step process involving phosphatidylinositide (PtdIns) phosphate-mediated recruitment of AKT and its upstream kinases, including 3-Phosphoinositide-dependent kinase 1 (PDK1), to...

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Detalles Bibliográficos
Autores principales:	Ding, Zhiyong, Liang, Jiyong, Li, Jin, Lu, Yiling, Ariyaratna, Vathsala, Lu, Zhimin, Davies, Michael A., Westwick, John K., Mills, Gordon B.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2845649/ https://www.ncbi.nlm.nih.gov/pubmed/20361045 http://dx.doi.org/10.1371/journal.pone.0009910

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