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Srs2: The “Odd-Job Man” in DNA repair

Homologous recombination plays a key role in the maintenance of genome integrity, especially during DNA replication and the repair of double-stranded DNA breaks (DSBs). Just a single un-repaired break can lead to aneuploidy, genetic aberrations or cell death. DSBs are caused by a vast number of both...

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Detalles Bibliográficos
Autores principales: Marini, Victoria, Krejci, Lumir
Formato: Texto
Lenguaje:English
Publicado: Elsevier 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2845805/
https://www.ncbi.nlm.nih.gov/pubmed/20096651
http://dx.doi.org/10.1016/j.dnarep.2010.01.007
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author Marini, Victoria
Krejci, Lumir
author_facet Marini, Victoria
Krejci, Lumir
author_sort Marini, Victoria
collection PubMed
description Homologous recombination plays a key role in the maintenance of genome integrity, especially during DNA replication and the repair of double-stranded DNA breaks (DSBs). Just a single un-repaired break can lead to aneuploidy, genetic aberrations or cell death. DSBs are caused by a vast number of both endogenous and exogenous agents including genotoxic chemicals or ionizing radiation, as well as through replication of a damaged template DNA or the replication fork collapse. It is essential for cell survival to recognise and process DSBs as well as other toxic intermediates and launch most appropriate repair mechanism. Many helicases have been implicated to play role in these processes, however their detail roles, specificities and co-operativity in the complex protein-protein interaction networks remain unclear. In this review we summarize the current knowledge about Saccharomyces cerevisiae helicase Srs2 and its effect on multiple DNA metabolic processes that generally affect genome stability. It would appear that Srs2 functions as an “Odd-Job Man” in these processes to make sure that the jobs proceed when and where they are needed.
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spelling pubmed-28458052010-03-31 Srs2: The “Odd-Job Man” in DNA repair Marini, Victoria Krejci, Lumir DNA Repair (Amst) Mini-Review Homologous recombination plays a key role in the maintenance of genome integrity, especially during DNA replication and the repair of double-stranded DNA breaks (DSBs). Just a single un-repaired break can lead to aneuploidy, genetic aberrations or cell death. DSBs are caused by a vast number of both endogenous and exogenous agents including genotoxic chemicals or ionizing radiation, as well as through replication of a damaged template DNA or the replication fork collapse. It is essential for cell survival to recognise and process DSBs as well as other toxic intermediates and launch most appropriate repair mechanism. Many helicases have been implicated to play role in these processes, however their detail roles, specificities and co-operativity in the complex protein-protein interaction networks remain unclear. In this review we summarize the current knowledge about Saccharomyces cerevisiae helicase Srs2 and its effect on multiple DNA metabolic processes that generally affect genome stability. It would appear that Srs2 functions as an “Odd-Job Man” in these processes to make sure that the jobs proceed when and where they are needed. Elsevier 2010-03-02 /pmc/articles/PMC2845805/ /pubmed/20096651 http://dx.doi.org/10.1016/j.dnarep.2010.01.007 Text en © 2010 Elsevier B.V. https://creativecommons.org/licenses/by/3.0/ Open Access under CC BY 3.0 (https://creativecommons.org/licenses/by/3.0/) license
spellingShingle Mini-Review
Marini, Victoria
Krejci, Lumir
Srs2: The “Odd-Job Man” in DNA repair
title Srs2: The “Odd-Job Man” in DNA repair
title_full Srs2: The “Odd-Job Man” in DNA repair
title_fullStr Srs2: The “Odd-Job Man” in DNA repair
title_full_unstemmed Srs2: The “Odd-Job Man” in DNA repair
title_short Srs2: The “Odd-Job Man” in DNA repair
title_sort srs2: the “odd-job man” in dna repair
topic Mini-Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2845805/
https://www.ncbi.nlm.nih.gov/pubmed/20096651
http://dx.doi.org/10.1016/j.dnarep.2010.01.007
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