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Structural magnetic resonance imaging predictors of responsiveness to cognitive behaviour therapy in psychosis

BACKGROUND: Responsiveness to cognitive behaviour therapy (CBT) in psychosis may have a neurological basis. This study aimed to determine whether improvement in symptoms following CBT for psychosis (CBTp) in people with schizophrenia is positively associated with pre-therapy grey matter volume in br...

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Autores principales: Premkumar, Preethi, Fannon, Dominic, Kuipers, Elizabeth, Peters, Emmanuelle R., Anilkumar, Ananatha P.P., Simmons, Andrew, Kumari, Veena
Formato: Texto
Lenguaje:English
Publicado: Elsevier Science Publisher B. V 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2845808/
https://www.ncbi.nlm.nih.gov/pubmed/19734016
http://dx.doi.org/10.1016/j.schres.2009.08.007
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author Premkumar, Preethi
Fannon, Dominic
Kuipers, Elizabeth
Peters, Emmanuelle R.
Anilkumar, Ananatha P.P.
Simmons, Andrew
Kumari, Veena
author_facet Premkumar, Preethi
Fannon, Dominic
Kuipers, Elizabeth
Peters, Emmanuelle R.
Anilkumar, Ananatha P.P.
Simmons, Andrew
Kumari, Veena
author_sort Premkumar, Preethi
collection PubMed
description BACKGROUND: Responsiveness to cognitive behaviour therapy (CBT) in psychosis may have a neurological basis. This study aimed to determine whether improvement in symptoms following CBT for psychosis (CBTp) in people with schizophrenia is positively associated with pre-therapy grey matter volume in brain regions involved in cognitive processing. METHODS: Sixty outpatients stable on medication with at least one distressing symptom of schizophrenia and willing to receive CBTp in addition to their standard care (SC), and 25 healthy participants underwent magnetic resonance imaging. Subsequently, 30 patients received CBTp (CBTp+SC; 25 completers) for 6–8 months and 30 continued with their standard care (SC; 19 completers). Symptoms in all patients were assessed (blindly) at entry and follow-up. RESULTS: The CBTp+SC and SC groups did not differ clinically at baseline, and only the CBTp+SC group showed improved symptoms at follow-up. Severity of baseline symptoms was not associated with CBTp responsiveness. Reduction with CBTp in positive symptoms was associated with greater right cerebellum (lobule VII) grey matter volume, in negative symptoms with left precentral gyrus and right inferior parietal lobule grey matter volumes, and in general psychopathology with greater right superior temporal gyrus, cuneus and cerebellum (Crus I) grey matter volumes. Grey matter volume in these brain areas did not correlate with the severity of baseline symptoms. CONCLUSION: Grey matter volume of the frontal, temporal, parietal and cerebellar areas that are known to be involved in the co-ordination of mental activity, cognitive flexibility, and verbal learning and memory predict responsiveness to CBTp in patients with psychosis.
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spelling pubmed-28458082010-03-31 Structural magnetic resonance imaging predictors of responsiveness to cognitive behaviour therapy in psychosis Premkumar, Preethi Fannon, Dominic Kuipers, Elizabeth Peters, Emmanuelle R. Anilkumar, Ananatha P.P. Simmons, Andrew Kumari, Veena Schizophr Res Article BACKGROUND: Responsiveness to cognitive behaviour therapy (CBT) in psychosis may have a neurological basis. This study aimed to determine whether improvement in symptoms following CBT for psychosis (CBTp) in people with schizophrenia is positively associated with pre-therapy grey matter volume in brain regions involved in cognitive processing. METHODS: Sixty outpatients stable on medication with at least one distressing symptom of schizophrenia and willing to receive CBTp in addition to their standard care (SC), and 25 healthy participants underwent magnetic resonance imaging. Subsequently, 30 patients received CBTp (CBTp+SC; 25 completers) for 6–8 months and 30 continued with their standard care (SC; 19 completers). Symptoms in all patients were assessed (blindly) at entry and follow-up. RESULTS: The CBTp+SC and SC groups did not differ clinically at baseline, and only the CBTp+SC group showed improved symptoms at follow-up. Severity of baseline symptoms was not associated with CBTp responsiveness. Reduction with CBTp in positive symptoms was associated with greater right cerebellum (lobule VII) grey matter volume, in negative symptoms with left precentral gyrus and right inferior parietal lobule grey matter volumes, and in general psychopathology with greater right superior temporal gyrus, cuneus and cerebellum (Crus I) grey matter volumes. Grey matter volume in these brain areas did not correlate with the severity of baseline symptoms. CONCLUSION: Grey matter volume of the frontal, temporal, parietal and cerebellar areas that are known to be involved in the co-ordination of mental activity, cognitive flexibility, and verbal learning and memory predict responsiveness to CBTp in patients with psychosis. Elsevier Science Publisher B. V 2009-12 /pmc/articles/PMC2845808/ /pubmed/19734016 http://dx.doi.org/10.1016/j.schres.2009.08.007 Text en © 2009 Elsevier B.V. https://creativecommons.org/licenses/by/3.0/This is an open access article under the CC BY license (https://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Premkumar, Preethi
Fannon, Dominic
Kuipers, Elizabeth
Peters, Emmanuelle R.
Anilkumar, Ananatha P.P.
Simmons, Andrew
Kumari, Veena
Structural magnetic resonance imaging predictors of responsiveness to cognitive behaviour therapy in psychosis
title Structural magnetic resonance imaging predictors of responsiveness to cognitive behaviour therapy in psychosis
title_full Structural magnetic resonance imaging predictors of responsiveness to cognitive behaviour therapy in psychosis
title_fullStr Structural magnetic resonance imaging predictors of responsiveness to cognitive behaviour therapy in psychosis
title_full_unstemmed Structural magnetic resonance imaging predictors of responsiveness to cognitive behaviour therapy in psychosis
title_short Structural magnetic resonance imaging predictors of responsiveness to cognitive behaviour therapy in psychosis
title_sort structural magnetic resonance imaging predictors of responsiveness to cognitive behaviour therapy in psychosis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2845808/
https://www.ncbi.nlm.nih.gov/pubmed/19734016
http://dx.doi.org/10.1016/j.schres.2009.08.007
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