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Cortical grey matter volume and sensorimotor gating in schizophrenia
Prepulse inhibition (PPI) of the startle response, a cross-species measure of sensorimotor gating, provides a valuable tool to study the known inability of a large proportion of individuals with schizophrenia to effectively screen out irrelevant sensory input. The cortico-striato-pallido-thalamic ci...
Autores principales: | , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Masson
2008
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2845812/ https://www.ncbi.nlm.nih.gov/pubmed/18761134 http://dx.doi.org/10.1016/j.cortex.2007.11.007 |
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author | Kumari, Veena Fannon, Dominic Geyer, Mark A. Premkumar, Preethi Antonova, Elena Simmons, Andrew Kuipers, Elizabeth |
author_facet | Kumari, Veena Fannon, Dominic Geyer, Mark A. Premkumar, Preethi Antonova, Elena Simmons, Andrew Kuipers, Elizabeth |
author_sort | Kumari, Veena |
collection | PubMed |
description | Prepulse inhibition (PPI) of the startle response, a cross-species measure of sensorimotor gating, provides a valuable tool to study the known inability of a large proportion of individuals with schizophrenia to effectively screen out irrelevant sensory input. The cortico-striato-pallido-thalamic circuitry is thought to be responsible for modulation of PPI in experimental animals. The involvement of this circuitry in human PPI is supported by observations of deficient PPI in a number of neuropsychiatric disorders that are characterised by abnormalities at some level in this circuitry, and findings of recent functional neuroimaging studies in healthy participants. The current study sought to investigate the structural neural correlates of PPI in a sample of 42 stable male outpatients with schizophrenia. Participants underwent magnetic resonance imaging (MRI) at 1.5 T and were assessed (off-line) on acoustic PPI using electromyographic recordings of the orbicularis oculi muscle beneath the right eye. Optimised volumetric voxel-based morphometry implemented in SPM2 was used to investigate the relationship of PPI (prepulse onset-to-pulse onset interval 120 msec) to regional grey matter (GM) volumes. Significant positive correlations were obtained between PPI and GM volume in the dorsolateral prefrontal, middle frontal and the orbital/medial prefrontal cortices. Our findings are consistent with (a) previous suggestions of susceptibility of PPI to cognitive processes controlled in a ‘top down’ manner by the cortex and (b) the hypothesis that compromised neural resources in the frontal cortex contribute to reduced PPI in schizophrenia. |
format | Text |
id | pubmed-2845812 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | Masson |
record_format | MEDLINE/PubMed |
spelling | pubmed-28458122010-03-31 Cortical grey matter volume and sensorimotor gating in schizophrenia Kumari, Veena Fannon, Dominic Geyer, Mark A. Premkumar, Preethi Antonova, Elena Simmons, Andrew Kuipers, Elizabeth Cortex Research Report Prepulse inhibition (PPI) of the startle response, a cross-species measure of sensorimotor gating, provides a valuable tool to study the known inability of a large proportion of individuals with schizophrenia to effectively screen out irrelevant sensory input. The cortico-striato-pallido-thalamic circuitry is thought to be responsible for modulation of PPI in experimental animals. The involvement of this circuitry in human PPI is supported by observations of deficient PPI in a number of neuropsychiatric disorders that are characterised by abnormalities at some level in this circuitry, and findings of recent functional neuroimaging studies in healthy participants. The current study sought to investigate the structural neural correlates of PPI in a sample of 42 stable male outpatients with schizophrenia. Participants underwent magnetic resonance imaging (MRI) at 1.5 T and were assessed (off-line) on acoustic PPI using electromyographic recordings of the orbicularis oculi muscle beneath the right eye. Optimised volumetric voxel-based morphometry implemented in SPM2 was used to investigate the relationship of PPI (prepulse onset-to-pulse onset interval 120 msec) to regional grey matter (GM) volumes. Significant positive correlations were obtained between PPI and GM volume in the dorsolateral prefrontal, middle frontal and the orbital/medial prefrontal cortices. Our findings are consistent with (a) previous suggestions of susceptibility of PPI to cognitive processes controlled in a ‘top down’ manner by the cortex and (b) the hypothesis that compromised neural resources in the frontal cortex contribute to reduced PPI in schizophrenia. Masson 2008-10 /pmc/articles/PMC2845812/ /pubmed/18761134 http://dx.doi.org/10.1016/j.cortex.2007.11.007 Text en © 2008 Elsevier Srl. All rights reserved. https://creativecommons.org/licenses/by/3.0/ Open Access under CC BY 3.0 (https://creativecommons.org/licenses/by/3.0/) license |
spellingShingle | Research Report Kumari, Veena Fannon, Dominic Geyer, Mark A. Premkumar, Preethi Antonova, Elena Simmons, Andrew Kuipers, Elizabeth Cortical grey matter volume and sensorimotor gating in schizophrenia |
title | Cortical grey matter volume and sensorimotor gating in schizophrenia |
title_full | Cortical grey matter volume and sensorimotor gating in schizophrenia |
title_fullStr | Cortical grey matter volume and sensorimotor gating in schizophrenia |
title_full_unstemmed | Cortical grey matter volume and sensorimotor gating in schizophrenia |
title_short | Cortical grey matter volume and sensorimotor gating in schizophrenia |
title_sort | cortical grey matter volume and sensorimotor gating in schizophrenia |
topic | Research Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2845812/ https://www.ncbi.nlm.nih.gov/pubmed/18761134 http://dx.doi.org/10.1016/j.cortex.2007.11.007 |
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