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A flexible sequential learning deficit in patients with Parkinson’s disease: a 2 × 8 button-press task

A 2 × 8 button-press task is a sequential hand movement task in which subjects are required to press eight pairs of buttons as accurately and quickly as possible. The 2 × 8 task allows us to examine flexible sequential learning, more aptly called sequence-unselective learning. Sequence-unselective l...

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Autores principales: Mochizuki-Kawai, Hiroko, Mochizuki, Satoshi, Kawamura, Mitsuru
Formato: Texto
Lenguaje:English
Publicado: Springer-Verlag 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2845884/
https://www.ncbi.nlm.nih.gov/pubmed/20020114
http://dx.doi.org/10.1007/s00221-009-2119-4
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author Mochizuki-Kawai, Hiroko
Mochizuki, Satoshi
Kawamura, Mitsuru
author_facet Mochizuki-Kawai, Hiroko
Mochizuki, Satoshi
Kawamura, Mitsuru
author_sort Mochizuki-Kawai, Hiroko
collection PubMed
description A 2 × 8 button-press task is a sequential hand movement task in which subjects are required to press eight pairs of buttons as accurately and quickly as possible. The 2 × 8 task allows us to examine flexible sequential learning, more aptly called sequence-unselective learning. Sequence-unselective learning is observed after repeated experiences with the task, when subjects have shown good progress in learning, with new sequences as well as previously learned ones. Although cognitive inflexibility has been reported in patients with Parkinson’s disease (PD), there have been few studies investigating their flexibility in sequential learning. We examined PD patients’ ability for sequence-unselective learning through the use of a 2 × 8 button-press task. In the first session, PD patients and subjects from the control group performed a sequential 2 × 8 task until the learning criterion was fulfilled (Session 1). After 1 month, they participated in other sessions: one involving the learned sequence (Session 2) and another involving the new sequence (Session 3). We found that PD patients made more errors than the normal control subjects only when learning the new sequence (Session 3) (P < 0.01). In Session 3, control subjects reached the learning target with fewer errors than in the Session 1 (normal sequence-unselective learning), whereas the PD patients did not exhibit such an improvement. Our results revealed a sequence-unselective deficit in PD patients. The deficit may help to emphasize the cognitive and physical inflexibility of PD.
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spelling pubmed-28458842010-04-05 A flexible sequential learning deficit in patients with Parkinson’s disease: a 2 × 8 button-press task Mochizuki-Kawai, Hiroko Mochizuki, Satoshi Kawamura, Mitsuru Exp Brain Res Research Article A 2 × 8 button-press task is a sequential hand movement task in which subjects are required to press eight pairs of buttons as accurately and quickly as possible. The 2 × 8 task allows us to examine flexible sequential learning, more aptly called sequence-unselective learning. Sequence-unselective learning is observed after repeated experiences with the task, when subjects have shown good progress in learning, with new sequences as well as previously learned ones. Although cognitive inflexibility has been reported in patients with Parkinson’s disease (PD), there have been few studies investigating their flexibility in sequential learning. We examined PD patients’ ability for sequence-unselective learning through the use of a 2 × 8 button-press task. In the first session, PD patients and subjects from the control group performed a sequential 2 × 8 task until the learning criterion was fulfilled (Session 1). After 1 month, they participated in other sessions: one involving the learned sequence (Session 2) and another involving the new sequence (Session 3). We found that PD patients made more errors than the normal control subjects only when learning the new sequence (Session 3) (P < 0.01). In Session 3, control subjects reached the learning target with fewer errors than in the Session 1 (normal sequence-unselective learning), whereas the PD patients did not exhibit such an improvement. Our results revealed a sequence-unselective deficit in PD patients. The deficit may help to emphasize the cognitive and physical inflexibility of PD. Springer-Verlag 2009-12-18 2010 /pmc/articles/PMC2845884/ /pubmed/20020114 http://dx.doi.org/10.1007/s00221-009-2119-4 Text en © The Author(s) 2009 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Research Article
Mochizuki-Kawai, Hiroko
Mochizuki, Satoshi
Kawamura, Mitsuru
A flexible sequential learning deficit in patients with Parkinson’s disease: a 2 × 8 button-press task
title A flexible sequential learning deficit in patients with Parkinson’s disease: a 2 × 8 button-press task
title_full A flexible sequential learning deficit in patients with Parkinson’s disease: a 2 × 8 button-press task
title_fullStr A flexible sequential learning deficit in patients with Parkinson’s disease: a 2 × 8 button-press task
title_full_unstemmed A flexible sequential learning deficit in patients with Parkinson’s disease: a 2 × 8 button-press task
title_short A flexible sequential learning deficit in patients with Parkinson’s disease: a 2 × 8 button-press task
title_sort flexible sequential learning deficit in patients with parkinson’s disease: a 2 × 8 button-press task
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2845884/
https://www.ncbi.nlm.nih.gov/pubmed/20020114
http://dx.doi.org/10.1007/s00221-009-2119-4
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