Synthesis, Antiinflammatory and Antibacterial Activity of Novel Indolyl-isoxazoles

Chalcones were synthesized by reacting indole-3-aldehyde, prepared by Vilsemeir Haack reaction with 4-substituted acetophenone in ethanolic KOH solution. These chalcones were immediately reacted with hydroxylamine hydrochloride in presence of glacial acetic acid as reagent to obtain the correspondin...

Descripción completa

Detalles Bibliográficos
Autores principales: Panda, S. S., Chowdary, P. V. R, Jayashree, B. S.
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications 2009
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2846477/
https://www.ncbi.nlm.nih.gov/pubmed/20376225
http://dx.doi.org/10.4103/0250-474X.59554
_version_ 1782179480584847360
author Panda, S. S.
Chowdary, P. V. R
Jayashree, B. S.
author_facet Panda, S. S.
Chowdary, P. V. R
Jayashree, B. S.
author_sort Panda, S. S.
collection PubMed
description Chalcones were synthesized by reacting indole-3-aldehyde, prepared by Vilsemeir Haack reaction with 4-substituted acetophenone in ethanolic KOH solution. These chalcones were immediately reacted with hydroxylamine hydrochloride in presence of glacial acetic acid as reagent to obtain the corresponding isoxazole derivatives. The synthesized heterocycles were characterized on the basis of physical, chemical tests and spectroscopic data. These compounds were tested for the acute antiinflammatory activity and antibacterial activity using carrageenan-induced rat paw edema method and cup-plate method, respectively.
format Text
id pubmed-2846477
institution National Center for Biotechnology Information
language English
publishDate 2009
publisher Medknow Publications
record_format MEDLINE/PubMed
spelling pubmed-28464772010-04-06 Synthesis, Antiinflammatory and Antibacterial Activity of Novel Indolyl-isoxazoles Panda, S. S. Chowdary, P. V. R Jayashree, B. S. Indian J Pharm Sci Short Communication Chalcones were synthesized by reacting indole-3-aldehyde, prepared by Vilsemeir Haack reaction with 4-substituted acetophenone in ethanolic KOH solution. These chalcones were immediately reacted with hydroxylamine hydrochloride in presence of glacial acetic acid as reagent to obtain the corresponding isoxazole derivatives. The synthesized heterocycles were characterized on the basis of physical, chemical tests and spectroscopic data. These compounds were tested for the acute antiinflammatory activity and antibacterial activity using carrageenan-induced rat paw edema method and cup-plate method, respectively. Medknow Publications 2009 /pmc/articles/PMC2846477/ /pubmed/20376225 http://dx.doi.org/10.4103/0250-474X.59554 Text en © Indian Journal of Pharmaceutical Sciences http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Communication
Panda, S. S.
Chowdary, P. V. R
Jayashree, B. S.
Synthesis, Antiinflammatory and Antibacterial Activity of Novel Indolyl-isoxazoles
title Synthesis, Antiinflammatory and Antibacterial Activity of Novel Indolyl-isoxazoles
title_full Synthesis, Antiinflammatory and Antibacterial Activity of Novel Indolyl-isoxazoles
title_fullStr Synthesis, Antiinflammatory and Antibacterial Activity of Novel Indolyl-isoxazoles
title_full_unstemmed Synthesis, Antiinflammatory and Antibacterial Activity of Novel Indolyl-isoxazoles
title_short Synthesis, Antiinflammatory and Antibacterial Activity of Novel Indolyl-isoxazoles
title_sort synthesis, antiinflammatory and antibacterial activity of novel indolyl-isoxazoles
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2846477/
https://www.ncbi.nlm.nih.gov/pubmed/20376225
http://dx.doi.org/10.4103/0250-474X.59554
work_keys_str_mv AT pandass synthesisantiinflammatoryandantibacterialactivityofnovelindolylisoxazoles
AT chowdarypvr synthesisantiinflammatoryandantibacterialactivityofnovelindolylisoxazoles
AT jayashreebs synthesisantiinflammatoryandantibacterialactivityofnovelindolylisoxazoles

Ejemplares similares