Nanoemulsion based Intranasal Delivery of Antimigraine Drugs for Nose to Brain Targeting

The objective of this study was to develop intranasal nanoemulsion and gel formulations for rizatriptan benzoate for prolonged action. Nanoemulsion formulations were prepared by constructing pseudo-ternary phase diagrams using lipophilic and hydrophilic surfactants and water. Various mucoadhesive ag...

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Detalles Bibliográficos
Autores principales: Bhanushali, R. S., Gatne, M. M., Gaikwad, R. V., Bajaj, A. N., Morde, M. A.
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications 2009
Materias:
Abstracts
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2846483/
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author Bhanushali, R. S.
Gatne, M. M.
Gaikwad, R. V.
Bajaj, A. N.
Morde, M. A.
author_facet Bhanushali, R. S.
Gatne, M. M.
Gaikwad, R. V.
Bajaj, A. N.
Morde, M. A.
author_sort Bhanushali, R. S.
collection PubMed
description The objective of this study was to develop intranasal nanoemulsion and gel formulations for rizatriptan benzoate for prolonged action. Nanoemulsion formulations were prepared by constructing pseudo-ternary phase diagrams using lipophilic and hydrophilic surfactants and water. Various mucoadhesive agents were tried out to form thermo-triggered mucoadhesive nanoemulsions. Mucoadhesive gel formulations of rizatriptan were prepared using different ratios of HPMC and Carbopol 980. Comparative evaluation of intranasal nanoemulsions and intranasal mucoadhesive gels indicated that greater brain-targeting could be achieved with nanoemulsions.
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spelling pubmed-28464832010-04-06 Nanoemulsion based Intranasal Delivery of Antimigraine Drugs for Nose to Brain Targeting Bhanushali, R. S. Gatne, M. M. Gaikwad, R. V. Bajaj, A. N. Morde, M. A. Indian J Pharm Sci Abstracts The objective of this study was to develop intranasal nanoemulsion and gel formulations for rizatriptan benzoate for prolonged action. Nanoemulsion formulations were prepared by constructing pseudo-ternary phase diagrams using lipophilic and hydrophilic surfactants and water. Various mucoadhesive agents were tried out to form thermo-triggered mucoadhesive nanoemulsions. Mucoadhesive gel formulations of rizatriptan were prepared using different ratios of HPMC and Carbopol 980. Comparative evaluation of intranasal nanoemulsions and intranasal mucoadhesive gels indicated that greater brain-targeting could be achieved with nanoemulsions. Medknow Publications 2009 /pmc/articles/PMC2846483/ Text en © Indian Journal of Pharmaceutical Sciences http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Abstracts
Bhanushali, R. S.
Gatne, M. M.
Gaikwad, R. V.
Bajaj, A. N.
Morde, M. A.
Nanoemulsion based Intranasal Delivery of Antimigraine Drugs for Nose to Brain Targeting
title Nanoemulsion based Intranasal Delivery of Antimigraine Drugs for Nose to Brain Targeting
title_full Nanoemulsion based Intranasal Delivery of Antimigraine Drugs for Nose to Brain Targeting
title_fullStr Nanoemulsion based Intranasal Delivery of Antimigraine Drugs for Nose to Brain Targeting
title_full_unstemmed Nanoemulsion based Intranasal Delivery of Antimigraine Drugs for Nose to Brain Targeting
title_short Nanoemulsion based Intranasal Delivery of Antimigraine Drugs for Nose to Brain Targeting
title_sort nanoemulsion based intranasal delivery of antimigraine drugs for nose to brain targeting
topic Abstracts
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2846483/
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AT bajajan nanoemulsionbasedintranasaldeliveryofantimigrainedrugsfornosetobraintargeting
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