Improvement of Inhalation Profile of DPI Formulations by Carrier Treatment with Magnesium Stearate

In the present study, the applicability of magnesium stearate-treated lactose carrier particles was evaluated to improve the inhalation performance of catalase microspheres. Bovine liver catalase microspheres with different stabilizers were prepared by spray drying. For the surface modification, lac...

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Detalles Bibliográficos
Autores principales: Hazare, Shruti, Menon, Mala
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications 2009
Materias:
Abstract
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2846491/
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author Hazare, Shruti
Menon, Mala
author_facet Hazare, Shruti
Menon, Mala
author_sort Hazare, Shruti
collection PubMed
description In the present study, the applicability of magnesium stearate-treated lactose carrier particles was evaluated to improve the inhalation performance of catalase microspheres. Bovine liver catalase microspheres with different stabilizers were prepared by spray drying. For the surface modification, lactose products were treated with 1 and 2% magnesium stearate by manual mixing and gently passed through a # 60 size mesh. The results revealed that magnesium stearate can be applied as a performance improver for catalase microsphere based DPI formulations.
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spelling pubmed-28464912010-04-06 Improvement of Inhalation Profile of DPI Formulations by Carrier Treatment with Magnesium Stearate Hazare, Shruti Menon, Mala Indian J Pharm Sci Abstract In the present study, the applicability of magnesium stearate-treated lactose carrier particles was evaluated to improve the inhalation performance of catalase microspheres. Bovine liver catalase microspheres with different stabilizers were prepared by spray drying. For the surface modification, lactose products were treated with 1 and 2% magnesium stearate by manual mixing and gently passed through a # 60 size mesh. The results revealed that magnesium stearate can be applied as a performance improver for catalase microsphere based DPI formulations. Medknow Publications 2009 /pmc/articles/PMC2846491/ Text en © Indian Journal of Pharmaceutical Sciences http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Abstract
Hazare, Shruti
Menon, Mala
Improvement of Inhalation Profile of DPI Formulations by Carrier Treatment with Magnesium Stearate
title Improvement of Inhalation Profile of DPI Formulations by Carrier Treatment with Magnesium Stearate
title_full Improvement of Inhalation Profile of DPI Formulations by Carrier Treatment with Magnesium Stearate
title_fullStr Improvement of Inhalation Profile of DPI Formulations by Carrier Treatment with Magnesium Stearate
title_full_unstemmed Improvement of Inhalation Profile of DPI Formulations by Carrier Treatment with Magnesium Stearate
title_short Improvement of Inhalation Profile of DPI Formulations by Carrier Treatment with Magnesium Stearate
title_sort improvement of inhalation profile of dpi formulations by carrier treatment with magnesium stearate
topic Abstract
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2846491/
work_keys_str_mv AT hazareshruti improvementofinhalationprofileofdpiformulationsbycarriertreatmentwithmagnesiumstearate
AT menonmala improvementofinhalationprofileofdpiformulationsbycarriertreatmentwithmagnesiumstearate

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