Immunoregulation through IL-10 gene expression and the fate of cytotoxic T lymphocyte-mediated tumor immunotherapy

Gene analysis of tumor associated antigens revealed that tumor antigens are all normal gene product. Inducing tumor reactive cytotoxic T lymphocytes (CT) in the patients is same as inducing autoimmunity in the patients. Immunosuppressive cytokine interleukin-10 (IL-10) plays an important role in mai...

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Detalles Bibliográficos
Autor principal: Chakraborty, Nitya G.
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications 2009
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2846567/
https://www.ncbi.nlm.nih.gov/pubmed/20407642
http://dx.doi.org/10.4103/0971-6866.50862
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author Chakraborty, Nitya G.
author_facet Chakraborty, Nitya G.
author_sort Chakraborty, Nitya G.
collection PubMed
description Gene analysis of tumor associated antigens revealed that tumor antigens are all normal gene product. Inducing tumor reactive cytotoxic T lymphocytes (CT) in the patients is same as inducing autoimmunity in the patients. Immunosuppressive cytokine interleukin-10 (IL-10) plays an important role in maintaining homeostasis or tolerance. To break the tumor tolerance, blocking and IL-10 secretion or intervention in the pathways of IL-10 gene activation is indeed important.
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spelling pubmed-28465672010-04-20 Immunoregulation through IL-10 gene expression and the fate of cytotoxic T lymphocyte-mediated tumor immunotherapy Chakraborty, Nitya G. Indian J Hum Genet Review Article Gene analysis of tumor associated antigens revealed that tumor antigens are all normal gene product. Inducing tumor reactive cytotoxic T lymphocytes (CT) in the patients is same as inducing autoimmunity in the patients. Immunosuppressive cytokine interleukin-10 (IL-10) plays an important role in maintaining homeostasis or tolerance. To break the tumor tolerance, blocking and IL-10 secretion or intervention in the pathways of IL-10 gene activation is indeed important. Medknow Publications 2009 /pmc/articles/PMC2846567/ /pubmed/20407642 http://dx.doi.org/10.4103/0971-6866.50862 Text en © Indian Journal of Human Genetics http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Chakraborty, Nitya G.
Immunoregulation through IL-10 gene expression and the fate of cytotoxic T lymphocyte-mediated tumor immunotherapy
title Immunoregulation through IL-10 gene expression and the fate of cytotoxic T lymphocyte-mediated tumor immunotherapy
title_full Immunoregulation through IL-10 gene expression and the fate of cytotoxic T lymphocyte-mediated tumor immunotherapy
title_fullStr Immunoregulation through IL-10 gene expression and the fate of cytotoxic T lymphocyte-mediated tumor immunotherapy
title_full_unstemmed Immunoregulation through IL-10 gene expression and the fate of cytotoxic T lymphocyte-mediated tumor immunotherapy
title_short Immunoregulation through IL-10 gene expression and the fate of cytotoxic T lymphocyte-mediated tumor immunotherapy
title_sort immunoregulation through il-10 gene expression and the fate of cytotoxic t lymphocyte-mediated tumor immunotherapy
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2846567/
https://www.ncbi.nlm.nih.gov/pubmed/20407642
http://dx.doi.org/10.4103/0971-6866.50862
work_keys_str_mv AT chakrabortynityag immunoregulationthroughil10geneexpressionandthefateofcytotoxictlymphocytemediatedtumorimmunotherapy

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