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The Pathophysiology, Diagnosis and Treatment of Allergic Rhinitis

Treatment of AR requires a stepwise approach depending on the severity and duration of symptoms. Treatment options for AR consist of allergen avoidance, pharmacotherapy, immunotherapy and surgery. For the mechanisms of AR, anti-IgE antibody and specific antibody to cytokines such as IL-4 or IL-5 tha...

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Autor principal: Min, Yang-Gi
Formato: Texto
Lenguaje:English
Publicado: The Korean Academy of Asthma, Allergy and Clinical Immunology; The Korean Academy of Pediatric Allergy and Respiratory Disease 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2846743/
https://www.ncbi.nlm.nih.gov/pubmed/20358020
http://dx.doi.org/10.4168/aair.2010.2.2.65
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author Min, Yang-Gi
author_facet Min, Yang-Gi
author_sort Min, Yang-Gi
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description Treatment of AR requires a stepwise approach depending on the severity and duration of symptoms. Treatment options for AR consist of allergen avoidance, pharmacotherapy, immunotherapy and surgery. For the mechanisms of AR, anti-IgE antibody and specific antibody to cytokines such as IL-4 or IL-5 that correlate with allergic inflammation have recently emerged. SLIT is currently widely used due to its efficacy, safety and convenience, which replaces subcutaneous immunotherapy. Although allergen avoidance and immunotherapy are theoretically ideal, antihistamines and intranasal corticosteroids will play the main role in the management of AR until an innovative treatment develops. However, patients' main symptom, the duration and severity of AR, patients' compliance, safety of medication and cost-effectiveness should be considered when treatment options are chosen. In conclusion, physicians should be aware of etiology, pathophysiology, symptoms, signs and diseases related to AR in order to make a correct diagnosis and choose a proper treatment option for each patient.
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spelling pubmed-28467432010-04-01 The Pathophysiology, Diagnosis and Treatment of Allergic Rhinitis Min, Yang-Gi Allergy Asthma Immunol Res Review Treatment of AR requires a stepwise approach depending on the severity and duration of symptoms. Treatment options for AR consist of allergen avoidance, pharmacotherapy, immunotherapy and surgery. For the mechanisms of AR, anti-IgE antibody and specific antibody to cytokines such as IL-4 or IL-5 that correlate with allergic inflammation have recently emerged. SLIT is currently widely used due to its efficacy, safety and convenience, which replaces subcutaneous immunotherapy. Although allergen avoidance and immunotherapy are theoretically ideal, antihistamines and intranasal corticosteroids will play the main role in the management of AR until an innovative treatment develops. However, patients' main symptom, the duration and severity of AR, patients' compliance, safety of medication and cost-effectiveness should be considered when treatment options are chosen. In conclusion, physicians should be aware of etiology, pathophysiology, symptoms, signs and diseases related to AR in order to make a correct diagnosis and choose a proper treatment option for each patient. The Korean Academy of Asthma, Allergy and Clinical Immunology; The Korean Academy of Pediatric Allergy and Respiratory Disease 2010-04 2010-03-24 /pmc/articles/PMC2846743/ /pubmed/20358020 http://dx.doi.org/10.4168/aair.2010.2.2.65 Text en Copyright © 2010 The Korean Academy of Asthma, Allergy and Clinical Immunology • The Korean Academy of Pediatric Allergy and Respiratory Disease http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Min, Yang-Gi
The Pathophysiology, Diagnosis and Treatment of Allergic Rhinitis
title The Pathophysiology, Diagnosis and Treatment of Allergic Rhinitis
title_full The Pathophysiology, Diagnosis and Treatment of Allergic Rhinitis
title_fullStr The Pathophysiology, Diagnosis and Treatment of Allergic Rhinitis
title_full_unstemmed The Pathophysiology, Diagnosis and Treatment of Allergic Rhinitis
title_short The Pathophysiology, Diagnosis and Treatment of Allergic Rhinitis
title_sort pathophysiology, diagnosis and treatment of allergic rhinitis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2846743/
https://www.ncbi.nlm.nih.gov/pubmed/20358020
http://dx.doi.org/10.4168/aair.2010.2.2.65
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