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GPG-NH(2 )acts via the metabolite αHGA to target HIV-1 Env to the ER-associated protein degradation pathway
BACKGROUND: The synthetic peptide glycyl-prolyl-glycine amide (GPG-NH(2)) was previously shown to abolish the ability of HIV-1 particles to fuse with the target cells, by reducing the content of the viral envelope glycoprotein (Env) in progeny HIV-1 particles. The loss of Env was found to result fro...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2846875/ https://www.ncbi.nlm.nih.gov/pubmed/20230608 http://dx.doi.org/10.1186/1742-4690-7-20 |