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Developmental and oncogenic effects of Insulin-like Growth Factor-I in Ptc1(+/- )mouse cerebellum

BACKGROUND: Medulloblastoma is amongst the most common malignant brain tumors in childhood, arising from neoplastic transformation of granule neuron precursors (GNPs) of the cerebellum via deregulation of pathways involved in cerebellar development. Deregulation of the Sonic hedgehog/Patched1 (Shh/P...

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Detalles Bibliográficos
Autores principales:	Tanori, Mirella, Santone, Melissa, Mancuso, Mariateresa, Pasquali, Emanuela, Leonardi, Simona, Di Majo, Vincenzo, Rebessi, Simonetta, Saran, Anna, Pazzaglia, Simonetta
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2010
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2846887/ https://www.ncbi.nlm.nih.gov/pubmed/20214787 http://dx.doi.org/10.1186/1476-4598-9-53

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