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Behçet’s Disease: an Insight from a Cardiologist’s Point of View

Behçet's disease (BD) is an enigmatic inflammatory disorder, with vasculitis (perivasculitis) underlying pathophysiology of its multisystemic affections. Venous pathology and thrombotic complications are hallmarks of BD. However, it has been increasingly recognized that cardiac involvement and...

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Detalles Bibliográficos
Autores principales: Cocco, Giuseppe, Gasparyan, Armen Yuri
Formato: Texto
Lenguaje:English
Publicado: Bentham Open 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2847211/
https://www.ncbi.nlm.nih.gov/pubmed/20360978
http://dx.doi.org/10.2174/1874192401004020063
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author Cocco, Giuseppe
Gasparyan, Armen Yuri
author_facet Cocco, Giuseppe
Gasparyan, Armen Yuri
author_sort Cocco, Giuseppe
collection PubMed
description Behçet's disease (BD) is an enigmatic inflammatory disorder, with vasculitis (perivasculitis) underlying pathophysiology of its multisystemic affections. Venous pathology and thrombotic complications are hallmarks of BD. However, it has been increasingly recognized that cardiac involvement and arterial complications (aneurysms, pseudoaneurysms, rupture and thrombosis) are important part of the course of BD. Pericarditis, myocardial (diastolic and/or systolic dysfunction), valvular and coronary (thrombosis, aneurysms, rupture) involvement, intracardiac thrombi (predominantly right-sided) are, probably, the most frequent cardiac manifestations. Treatment of cardiovascular involvement in BD is largely empirical and aimed at suppression of vasculitis. The most challenging seems to be the treatment of arterial aneurysms and thromboses due to the associated risk of bleedings. Cardiologists should always bear in mind potential threats of (a)symptomatic cardiovascular involvement in BD.
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spelling pubmed-28472112010-04-01 Behçet’s Disease: an Insight from a Cardiologist’s Point of View Cocco, Giuseppe Gasparyan, Armen Yuri Open Cardiovasc Med J Article Behçet's disease (BD) is an enigmatic inflammatory disorder, with vasculitis (perivasculitis) underlying pathophysiology of its multisystemic affections. Venous pathology and thrombotic complications are hallmarks of BD. However, it has been increasingly recognized that cardiac involvement and arterial complications (aneurysms, pseudoaneurysms, rupture and thrombosis) are important part of the course of BD. Pericarditis, myocardial (diastolic and/or systolic dysfunction), valvular and coronary (thrombosis, aneurysms, rupture) involvement, intracardiac thrombi (predominantly right-sided) are, probably, the most frequent cardiac manifestations. Treatment of cardiovascular involvement in BD is largely empirical and aimed at suppression of vasculitis. The most challenging seems to be the treatment of arterial aneurysms and thromboses due to the associated risk of bleedings. Cardiologists should always bear in mind potential threats of (a)symptomatic cardiovascular involvement in BD. Bentham Open 2010-02-23 /pmc/articles/PMC2847211/ /pubmed/20360978 http://dx.doi.org/10.2174/1874192401004020063 Text en © Cocco and Gasparyan; Licensee Bentham Open. http://creativecommons.org/licenses/by-nc/3.0/ This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
spellingShingle Article
Cocco, Giuseppe
Gasparyan, Armen Yuri
Behçet’s Disease: an Insight from a Cardiologist’s Point of View
title Behçet’s Disease: an Insight from a Cardiologist’s Point of View
title_full Behçet’s Disease: an Insight from a Cardiologist’s Point of View
title_fullStr Behçet’s Disease: an Insight from a Cardiologist’s Point of View
title_full_unstemmed Behçet’s Disease: an Insight from a Cardiologist’s Point of View
title_short Behçet’s Disease: an Insight from a Cardiologist’s Point of View
title_sort behçet’s disease: an insight from a cardiologist’s point of view
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2847211/
https://www.ncbi.nlm.nih.gov/pubmed/20360978
http://dx.doi.org/10.2174/1874192401004020063
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