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The N-terminus of hTERT contains a DNA-binding domain and is required for telomerase activity and cellular immortalization

Telomerase defers the onset of telomere damage-induced signaling and cellular senescence by adding DNA onto chromosome ends. The ability of telomerase to elongate single-stranded telomeric DNA depends on the reverse transcriptase domain of TERT, and also relies on protein:DNA contacts outside the ac...

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Detalles Bibliográficos
Autores principales:	Sealey, David C. F., Zheng, Le, Taboski, Michael A. S., Cruickshank, Jennifer, Ikura, Mitsuhiko, Harrington, Lea A.
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2010
Materias:	Nucleic Acid Enzymes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2847226/ https://www.ncbi.nlm.nih.gov/pubmed/20034955 http://dx.doi.org/10.1093/nar/gkp1160

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