Lovastatin induces apoptosis of ovarian cancer cells and synergizes with doxorubicin: potential therapeutic relevance

BACKGROUND: Ovarian carcinoma is a rarely curable disease, for which new treatment options are required. As agents that block HMG-CoA reductase and the mevalonate pathway, the statin family of drugs are used in the treatment of hypercholesterolemia and have been shown to trigger apoptosis in a tumor...

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Detalles Bibliográficos
Autores principales: Martirosyan, Anna, Clendening, James W, Goard, Carolyn A, Penn, Linda Z
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2847546/
https://www.ncbi.nlm.nih.gov/pubmed/20298590
http://dx.doi.org/10.1186/1471-2407-10-103

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2847546/
https://www.ncbi.nlm.nih.gov/pubmed/20298590
http://dx.doi.org/10.1186/1471-2407-10-103

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