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Vascular Function and Inflammation in Rheumatoid Arthritis: the Role of Physical Activity
Inflammation disturbs biochemical pathways involved in homeostasis of the endothelium. Research has established clear links between inflammatory mediators, particularly C-reactive protein and tumour necrosis factor alpha, endothelial dysfunction, and atherosclerosis. Endothelial dysfunction and athe...
Autores principales: | , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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Bentham Open
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2847820/ https://www.ncbi.nlm.nih.gov/pubmed/20361002 http://dx.doi.org/10.2174/1874192401004020089 |
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author | Metsios, George S Stavropoulos-Kalinoglou, Antonios Sandoo, Aamer van Zanten, Jet J.C.S. Veldhuijzen Toms, Tracey E John, Holly Kitas, George D |
author_facet | Metsios, George S Stavropoulos-Kalinoglou, Antonios Sandoo, Aamer van Zanten, Jet J.C.S. Veldhuijzen Toms, Tracey E John, Holly Kitas, George D |
author_sort | Metsios, George S |
collection | PubMed |
description | Inflammation disturbs biochemical pathways involved in homeostasis of the endothelium. Research has established clear links between inflammatory mediators, particularly C-reactive protein and tumour necrosis factor alpha, endothelial dysfunction, and atherosclerosis. Endothelial dysfunction and atherosclerosis may be subclinical at early stages, and thus the ability to detect them with non-invasive techniques is crucially important, particularly in populations at increased risk for cardiovascular disease, such as those with rheumatoid arthritis. This may allow the identification of interventions that may reverse these processes early on. One of the best non-pharmacological interventions that may achieve this is physical activity. This review explores the associations between inflammation, endothelial dysfunction, and atherosclerosis and discusses the role of exercise in blocking specific pathways in the inflammation, endothelial dysfunction - atherosclerosis network. |
format | Text |
id | pubmed-2847820 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Bentham Open |
record_format | MEDLINE/PubMed |
spelling | pubmed-28478202010-04-01 Vascular Function and Inflammation in Rheumatoid Arthritis: the Role of Physical Activity Metsios, George S Stavropoulos-Kalinoglou, Antonios Sandoo, Aamer van Zanten, Jet J.C.S. Veldhuijzen Toms, Tracey E John, Holly Kitas, George D Open Cardiovasc Med J Article Inflammation disturbs biochemical pathways involved in homeostasis of the endothelium. Research has established clear links between inflammatory mediators, particularly C-reactive protein and tumour necrosis factor alpha, endothelial dysfunction, and atherosclerosis. Endothelial dysfunction and atherosclerosis may be subclinical at early stages, and thus the ability to detect them with non-invasive techniques is crucially important, particularly in populations at increased risk for cardiovascular disease, such as those with rheumatoid arthritis. This may allow the identification of interventions that may reverse these processes early on. One of the best non-pharmacological interventions that may achieve this is physical activity. This review explores the associations between inflammation, endothelial dysfunction, and atherosclerosis and discusses the role of exercise in blocking specific pathways in the inflammation, endothelial dysfunction - atherosclerosis network. Bentham Open 2010-02-23 /pmc/articles/PMC2847820/ /pubmed/20361002 http://dx.doi.org/10.2174/1874192401004020089 Text en © Metsios et al.; Licensee Bentham Open. http://creativecommons.org/licenses/by-nc/3.0/ This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited. |
spellingShingle | Article Metsios, George S Stavropoulos-Kalinoglou, Antonios Sandoo, Aamer van Zanten, Jet J.C.S. Veldhuijzen Toms, Tracey E John, Holly Kitas, George D Vascular Function and Inflammation in Rheumatoid Arthritis: the Role of Physical Activity |
title | Vascular Function and Inflammation in Rheumatoid Arthritis: the Role of Physical Activity |
title_full | Vascular Function and Inflammation in Rheumatoid Arthritis: the Role of Physical Activity |
title_fullStr | Vascular Function and Inflammation in Rheumatoid Arthritis: the Role of Physical Activity |
title_full_unstemmed | Vascular Function and Inflammation in Rheumatoid Arthritis: the Role of Physical Activity |
title_short | Vascular Function and Inflammation in Rheumatoid Arthritis: the Role of Physical Activity |
title_sort | vascular function and inflammation in rheumatoid arthritis: the role of physical activity |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2847820/ https://www.ncbi.nlm.nih.gov/pubmed/20361002 http://dx.doi.org/10.2174/1874192401004020089 |
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