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Vascular Function and Inflammation in Rheumatoid Arthritis: the Role of Physical Activity

Inflammation disturbs biochemical pathways involved in homeostasis of the endothelium. Research has established clear links between inflammatory mediators, particularly C-reactive protein and tumour necrosis factor alpha, endothelial dysfunction, and atherosclerosis. Endothelial dysfunction and athe...

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Autores principales: Metsios, George S, Stavropoulos-Kalinoglou, Antonios, Sandoo, Aamer, van Zanten, Jet J.C.S. Veldhuijzen, Toms, Tracey E, John, Holly, Kitas, George D
Formato: Texto
Lenguaje:English
Publicado: Bentham Open 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2847820/
https://www.ncbi.nlm.nih.gov/pubmed/20361002
http://dx.doi.org/10.2174/1874192401004020089
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author Metsios, George S
Stavropoulos-Kalinoglou, Antonios
Sandoo, Aamer
van Zanten, Jet J.C.S. Veldhuijzen
Toms, Tracey E
John, Holly
Kitas, George D
author_facet Metsios, George S
Stavropoulos-Kalinoglou, Antonios
Sandoo, Aamer
van Zanten, Jet J.C.S. Veldhuijzen
Toms, Tracey E
John, Holly
Kitas, George D
author_sort Metsios, George S
collection PubMed
description Inflammation disturbs biochemical pathways involved in homeostasis of the endothelium. Research has established clear links between inflammatory mediators, particularly C-reactive protein and tumour necrosis factor alpha, endothelial dysfunction, and atherosclerosis. Endothelial dysfunction and atherosclerosis may be subclinical at early stages, and thus the ability to detect them with non-invasive techniques is crucially important, particularly in populations at increased risk for cardiovascular disease, such as those with rheumatoid arthritis. This may allow the identification of interventions that may reverse these processes early on. One of the best non-pharmacological interventions that may achieve this is physical activity. This review explores the associations between inflammation, endothelial dysfunction, and atherosclerosis and discusses the role of exercise in blocking specific pathways in the inflammation, endothelial dysfunction - atherosclerosis network.
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spelling pubmed-28478202010-04-01 Vascular Function and Inflammation in Rheumatoid Arthritis: the Role of Physical Activity Metsios, George S Stavropoulos-Kalinoglou, Antonios Sandoo, Aamer van Zanten, Jet J.C.S. Veldhuijzen Toms, Tracey E John, Holly Kitas, George D Open Cardiovasc Med J Article Inflammation disturbs biochemical pathways involved in homeostasis of the endothelium. Research has established clear links between inflammatory mediators, particularly C-reactive protein and tumour necrosis factor alpha, endothelial dysfunction, and atherosclerosis. Endothelial dysfunction and atherosclerosis may be subclinical at early stages, and thus the ability to detect them with non-invasive techniques is crucially important, particularly in populations at increased risk for cardiovascular disease, such as those with rheumatoid arthritis. This may allow the identification of interventions that may reverse these processes early on. One of the best non-pharmacological interventions that may achieve this is physical activity. This review explores the associations between inflammation, endothelial dysfunction, and atherosclerosis and discusses the role of exercise in blocking specific pathways in the inflammation, endothelial dysfunction - atherosclerosis network. Bentham Open 2010-02-23 /pmc/articles/PMC2847820/ /pubmed/20361002 http://dx.doi.org/10.2174/1874192401004020089 Text en © Metsios et al.; Licensee Bentham Open. http://creativecommons.org/licenses/by-nc/3.0/ This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
spellingShingle Article
Metsios, George S
Stavropoulos-Kalinoglou, Antonios
Sandoo, Aamer
van Zanten, Jet J.C.S. Veldhuijzen
Toms, Tracey E
John, Holly
Kitas, George D
Vascular Function and Inflammation in Rheumatoid Arthritis: the Role of Physical Activity
title Vascular Function and Inflammation in Rheumatoid Arthritis: the Role of Physical Activity
title_full Vascular Function and Inflammation in Rheumatoid Arthritis: the Role of Physical Activity
title_fullStr Vascular Function and Inflammation in Rheumatoid Arthritis: the Role of Physical Activity
title_full_unstemmed Vascular Function and Inflammation in Rheumatoid Arthritis: the Role of Physical Activity
title_short Vascular Function and Inflammation in Rheumatoid Arthritis: the Role of Physical Activity
title_sort vascular function and inflammation in rheumatoid arthritis: the role of physical activity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2847820/
https://www.ncbi.nlm.nih.gov/pubmed/20361002
http://dx.doi.org/10.2174/1874192401004020089
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