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A single nucleotide polymorphism in the Bax gene promoter affects transcription and influences retinal ganglion cell death

Pro-apoptotic Bax is essential for RGC (retinal ganglion cell) death. Gene dosage experiments in mice, yielding a single wild-type Bax allele, indicated that genetic background was able to influence the cell death phenotype. DBA/2J(Bax+/−) mice exhibited complete resistance to nerve damage after 2 w...

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Detalles Bibliográficos
Autores principales:	Semaan, Sheila J, Li, Yan, Nickells, Robert W
Formato:	Texto
Lenguaje:	English
Publicado:	American Society for Neurochemistry 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2847828/ https://www.ncbi.nlm.nih.gov/pubmed/20360947 http://dx.doi.org/10.1042/AN20100003

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