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Effect of levosimendan in experimental verapamil- induced myocardial depression

BACKGROUND: Calcium antagonist overdose can cause severe deterioration of hemodynamics unresponsible to treatment with beta adrenergic inotropes. The aim of the study was to evaluate in an experimental model the effects of levosimendan during severe calcium antagonist intoxication. METHODS: Twelve l...

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Autores principales: Kurola, Jouni, Leppikangas, Heli, Magga, Jarkko, Lindgren, Leena, Kiviniemi, Vesa, Rutanen, Juha, Ruokonen, Esko
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2847962/
https://www.ncbi.nlm.nih.gov/pubmed/20222974
http://dx.doi.org/10.1186/1757-7241-18-12
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author Kurola, Jouni
Leppikangas, Heli
Magga, Jarkko
Lindgren, Leena
Kiviniemi, Vesa
Rutanen, Juha
Ruokonen, Esko
author_facet Kurola, Jouni
Leppikangas, Heli
Magga, Jarkko
Lindgren, Leena
Kiviniemi, Vesa
Rutanen, Juha
Ruokonen, Esko
author_sort Kurola, Jouni
collection PubMed
description BACKGROUND: Calcium antagonist overdose can cause severe deterioration of hemodynamics unresponsible to treatment with beta adrenergic inotropes. The aim of the study was to evaluate in an experimental model the effects of levosimendan during severe calcium antagonist intoxication. METHODS: Twelve landrace-pigs were intoxicated with intravenous verapamil at escalating infusion rates. The infusion containing 2.5 mg/ml verapamil was used aiming to a reduction of cardiac output by 40% from the baseline value. Intoxicated pigs were randomized into two groups: control (saline) and levosimendan (intravenous bolus). Inotropic effect was measured as a change in a maximum of the positive slope of the left ventricular pressure (LV dP/dt). The survival and hemodynamics of the animals were followed for 120 min after the targeted reduction of cardiac output. RESULTS: In the control group, five out of six pigs died during the experiment. In the levosimendan group, one pig died before completion of the experiment (p = 0.04). In the levosimendan group a change in LV dP/dt was positive in four out of six pigs compared to one out of six pigs in the control group (p = ns). CONCLUSIONS: In this experimental model, the use of levosimendan was associated with improved survival.
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spelling pubmed-28479622010-04-01 Effect of levosimendan in experimental verapamil- induced myocardial depression Kurola, Jouni Leppikangas, Heli Magga, Jarkko Lindgren, Leena Kiviniemi, Vesa Rutanen, Juha Ruokonen, Esko Scand J Trauma Resusc Emerg Med Original Research BACKGROUND: Calcium antagonist overdose can cause severe deterioration of hemodynamics unresponsible to treatment with beta adrenergic inotropes. The aim of the study was to evaluate in an experimental model the effects of levosimendan during severe calcium antagonist intoxication. METHODS: Twelve landrace-pigs were intoxicated with intravenous verapamil at escalating infusion rates. The infusion containing 2.5 mg/ml verapamil was used aiming to a reduction of cardiac output by 40% from the baseline value. Intoxicated pigs were randomized into two groups: control (saline) and levosimendan (intravenous bolus). Inotropic effect was measured as a change in a maximum of the positive slope of the left ventricular pressure (LV dP/dt). The survival and hemodynamics of the animals were followed for 120 min after the targeted reduction of cardiac output. RESULTS: In the control group, five out of six pigs died during the experiment. In the levosimendan group, one pig died before completion of the experiment (p = 0.04). In the levosimendan group a change in LV dP/dt was positive in four out of six pigs compared to one out of six pigs in the control group (p = ns). CONCLUSIONS: In this experimental model, the use of levosimendan was associated with improved survival. BioMed Central 2010-03-11 /pmc/articles/PMC2847962/ /pubmed/20222974 http://dx.doi.org/10.1186/1757-7241-18-12 Text en Copyright ©2010 Kurola et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research
Kurola, Jouni
Leppikangas, Heli
Magga, Jarkko
Lindgren, Leena
Kiviniemi, Vesa
Rutanen, Juha
Ruokonen, Esko
Effect of levosimendan in experimental verapamil- induced myocardial depression
title Effect of levosimendan in experimental verapamil- induced myocardial depression
title_full Effect of levosimendan in experimental verapamil- induced myocardial depression
title_fullStr Effect of levosimendan in experimental verapamil- induced myocardial depression
title_full_unstemmed Effect of levosimendan in experimental verapamil- induced myocardial depression
title_short Effect of levosimendan in experimental verapamil- induced myocardial depression
title_sort effect of levosimendan in experimental verapamil- induced myocardial depression
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2847962/
https://www.ncbi.nlm.nih.gov/pubmed/20222974
http://dx.doi.org/10.1186/1757-7241-18-12
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