Discovery and SAR exploration of N-aryl-N-(3-aryl-1,2,4-oxadiazol-5-yl)amines as potential therapeutic agents for prostate cancer

A new chemical series of antiproliferative compounds was identified via high-throughput screening on DU-145 human prostate carcinoma cell line (hit compound potency - 5.7 μM). Exploration of the two peripheral diversity vectors of the hit molecule in a hit-targeted library and testing of the resulti...

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Detalles Bibliográficos
Autores principales: Krasavin, Mikhail, Rufanov, Konstantin A, Sosnov, Andrey V, Karapetian, Ruben, Godovykh, Elena, Soldatkina, Olga, Lavrovsky, Yan, Gakh, Andrei A
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Preliminary Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2848039/
https://www.ncbi.nlm.nih.gov/pubmed/20214785
http://dx.doi.org/10.1186/1752-153X-4-4

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