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Population-based seroprevalence of HSV-2 and syphilis in Andhra Pradesh state of India

BACKGROUND: Understanding the prevalence and risk factors for common causes of ulcerative genital disease in the general population would inform current STI syndromic management and HIV testing strategies in high HIV prevalence regions of India. METHODS: Persons 15-49 years old from 32 rural and 34...

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Autores principales: Schneider, John A, Lakshmi, Vemu, Dandona, Rakhi, Kumar, G Anil, Sudha, Talasila, Dandona, Lalit
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2848152/
https://www.ncbi.nlm.nih.gov/pubmed/20214795
http://dx.doi.org/10.1186/1471-2334-10-59
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author Schneider, John A
Lakshmi, Vemu
Dandona, Rakhi
Kumar, G Anil
Sudha, Talasila
Dandona, Lalit
author_facet Schneider, John A
Lakshmi, Vemu
Dandona, Rakhi
Kumar, G Anil
Sudha, Talasila
Dandona, Lalit
author_sort Schneider, John A
collection PubMed
description BACKGROUND: Understanding the prevalence and risk factors for common causes of ulcerative genital disease in the general population would inform current STI syndromic management and HIV testing strategies in high HIV prevalence regions of India. METHODS: Persons 15-49 years old from 32 rural and 34 urban clusters were sampled using a stratified random method to represent adults in the high HIV prevalence Guntur district in Andhra Pradesh state. Interviews were conducted and dry blood spots were collected on 12,617 study participants. Testing for HSV-2 and syphilis was performed. RESULTS: Adjusted HSV-2 and syphilis seroprevalence rates were 4.70% and 2.08% for men and 7.07% and 1.42% for women. For men, tattooing, >3 lifetime sex partners, tobacco use, and sex with men in the past 6 months were associated with HSV-2 or syphilis (ORs, 1.66-2.95, p < 0.05). Male circumcision was positively associated with HSV-2 infection (OR, 1.37, p = 0.028) though this could be due to residual confounding. In women, greater than one lifetime partner remained significantly associated with HSV-2 in multivariate analysis (OR, 2.61; 95% CI, 1.39-4.87). Among all behavioral risk factors and other covariates in women and men, HIV infection exhibited the strongest association with HSV-2 and syphilis (ORs, 8.2-14.2, p < 0.001). The proportion of individuals with HSV-2 who were HIV infected was less than the proportion with syphilis who were HIV infected (11.8% vs. 22.7%; p = 0.001). CONCLUSIONS: Nearly one in four persons surveyed in this population-based study that were seroprevalent for syphilis, were also HIV infected. Common population risk factors for syphilis, HSV-2 and HIV and high rates of co-seroprevalence suggest that HIV testing, STI testing and service strategies for these would benefit from direct linkage in India.
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spelling pubmed-28481522010-04-01 Population-based seroprevalence of HSV-2 and syphilis in Andhra Pradesh state of India Schneider, John A Lakshmi, Vemu Dandona, Rakhi Kumar, G Anil Sudha, Talasila Dandona, Lalit BMC Infect Dis Research Article BACKGROUND: Understanding the prevalence and risk factors for common causes of ulcerative genital disease in the general population would inform current STI syndromic management and HIV testing strategies in high HIV prevalence regions of India. METHODS: Persons 15-49 years old from 32 rural and 34 urban clusters were sampled using a stratified random method to represent adults in the high HIV prevalence Guntur district in Andhra Pradesh state. Interviews were conducted and dry blood spots were collected on 12,617 study participants. Testing for HSV-2 and syphilis was performed. RESULTS: Adjusted HSV-2 and syphilis seroprevalence rates were 4.70% and 2.08% for men and 7.07% and 1.42% for women. For men, tattooing, >3 lifetime sex partners, tobacco use, and sex with men in the past 6 months were associated with HSV-2 or syphilis (ORs, 1.66-2.95, p < 0.05). Male circumcision was positively associated with HSV-2 infection (OR, 1.37, p = 0.028) though this could be due to residual confounding. In women, greater than one lifetime partner remained significantly associated with HSV-2 in multivariate analysis (OR, 2.61; 95% CI, 1.39-4.87). Among all behavioral risk factors and other covariates in women and men, HIV infection exhibited the strongest association with HSV-2 and syphilis (ORs, 8.2-14.2, p < 0.001). The proportion of individuals with HSV-2 who were HIV infected was less than the proportion with syphilis who were HIV infected (11.8% vs. 22.7%; p = 0.001). CONCLUSIONS: Nearly one in four persons surveyed in this population-based study that were seroprevalent for syphilis, were also HIV infected. Common population risk factors for syphilis, HSV-2 and HIV and high rates of co-seroprevalence suggest that HIV testing, STI testing and service strategies for these would benefit from direct linkage in India. BioMed Central 2010-03-09 /pmc/articles/PMC2848152/ /pubmed/20214795 http://dx.doi.org/10.1186/1471-2334-10-59 Text en Copyright ©2010 Schneider et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Schneider, John A
Lakshmi, Vemu
Dandona, Rakhi
Kumar, G Anil
Sudha, Talasila
Dandona, Lalit
Population-based seroprevalence of HSV-2 and syphilis in Andhra Pradesh state of India
title Population-based seroprevalence of HSV-2 and syphilis in Andhra Pradesh state of India
title_full Population-based seroprevalence of HSV-2 and syphilis in Andhra Pradesh state of India
title_fullStr Population-based seroprevalence of HSV-2 and syphilis in Andhra Pradesh state of India
title_full_unstemmed Population-based seroprevalence of HSV-2 and syphilis in Andhra Pradesh state of India
title_short Population-based seroprevalence of HSV-2 and syphilis in Andhra Pradesh state of India
title_sort population-based seroprevalence of hsv-2 and syphilis in andhra pradesh state of india
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2848152/
https://www.ncbi.nlm.nih.gov/pubmed/20214795
http://dx.doi.org/10.1186/1471-2334-10-59
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