Overexpression of the JmjC histone demethylase KDM5B in human carcinogenesis: involvement in the proliferation of cancer cells through the E2F/RB pathway

BACKGROUND: Although an increasing number of histone demethylases have been identified and biochemically characterized, their biological functions largely remain uncharacterized, particularly in the context of human diseases such as cancer. We investigated the role of KDM5B, a JmjC histone demethyla...

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Detalles Bibliográficos
Autores principales: Hayami, Shinya, Yoshimatsu, Masanori, Veerakumarasivam, Abhimanyu, Unoki, Motoko, Iwai, Yukiko, Tsunoda, Tatsuhiko, Field, Helen I, Kelly, John D, Neal, David E, Yamaue, Hiroki, Ponder, Bruce AJ, Nakamura, Yusuke, Hamamoto, Ryuji
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2848192/
https://www.ncbi.nlm.nih.gov/pubmed/20226085
http://dx.doi.org/10.1186/1476-4598-9-59

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