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The Use of Nuclear Imaging for Cardiac Resynchronization Therapy

Cardiac resynchronization therapy (CRT) has shown benefits in patients with end-stage heart failure, depressed left ventricular (LV) ejection fraction (≤ 35%), and prolonged QRS duration (≥ 120 ms). However, based on the conventional criteria, 20% to 40% of patients fail to respond to CRT. Studies h...

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Detalles Bibliográficos
Autores principales: Chen, Ji, Boogers, Mark M., Bax, Jeroen J., Soman, Prem, Garcia, Ernest V.
Formato: Texto
Lenguaje:English
Publicado: Current Science Inc. 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2848349/
https://www.ncbi.nlm.nih.gov/pubmed/20425175
http://dx.doi.org/10.1007/s11886-010-0086-9
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author Chen, Ji
Boogers, Mark M.
Bax, Jeroen J.
Soman, Prem
Garcia, Ernest V.
author_facet Chen, Ji
Boogers, Mark M.
Bax, Jeroen J.
Soman, Prem
Garcia, Ernest V.
author_sort Chen, Ji
collection PubMed
description Cardiac resynchronization therapy (CRT) has shown benefits in patients with end-stage heart failure, depressed left ventricular (LV) ejection fraction (≤ 35%), and prolonged QRS duration (≥ 120 ms). However, based on the conventional criteria, 20% to 40% of patients fail to respond to CRT. Studies have focused on important parameters for predicting CRT response, such as LV dyssynchrony, scar burden, LV lead position, and site of latest activation. Phase analysis allows nuclear cardiology modalities, such as gated blood-pool imaging and gated myocardial perfusion single photon emission computed tomography (GMPS), to assess LV dyssynchrony. Most importantly, GMPS with phase analysis has the potential of assessing LV dyssynchrony, scar burden, and site of late activation from a single acquisition, so that this technique may provide a one-stop shop for predicting CRT response. This article provides a summary on the role of nuclear cardiology in selecting patients for CRT, with emphasis on GMPS with phase analysis.
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spelling pubmed-28483492010-04-12 The Use of Nuclear Imaging for Cardiac Resynchronization Therapy Chen, Ji Boogers, Mark M. Bax, Jeroen J. Soman, Prem Garcia, Ernest V. Curr Cardiol Rep Article Cardiac resynchronization therapy (CRT) has shown benefits in patients with end-stage heart failure, depressed left ventricular (LV) ejection fraction (≤ 35%), and prolonged QRS duration (≥ 120 ms). However, based on the conventional criteria, 20% to 40% of patients fail to respond to CRT. Studies have focused on important parameters for predicting CRT response, such as LV dyssynchrony, scar burden, LV lead position, and site of latest activation. Phase analysis allows nuclear cardiology modalities, such as gated blood-pool imaging and gated myocardial perfusion single photon emission computed tomography (GMPS), to assess LV dyssynchrony. Most importantly, GMPS with phase analysis has the potential of assessing LV dyssynchrony, scar burden, and site of late activation from a single acquisition, so that this technique may provide a one-stop shop for predicting CRT response. This article provides a summary on the role of nuclear cardiology in selecting patients for CRT, with emphasis on GMPS with phase analysis. Current Science Inc. 2010-02-23 2010 /pmc/articles/PMC2848349/ /pubmed/20425175 http://dx.doi.org/10.1007/s11886-010-0086-9 Text en © The Author(s) 2010 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Article
Chen, Ji
Boogers, Mark M.
Bax, Jeroen J.
Soman, Prem
Garcia, Ernest V.
The Use of Nuclear Imaging for Cardiac Resynchronization Therapy
title The Use of Nuclear Imaging for Cardiac Resynchronization Therapy
title_full The Use of Nuclear Imaging for Cardiac Resynchronization Therapy
title_fullStr The Use of Nuclear Imaging for Cardiac Resynchronization Therapy
title_full_unstemmed The Use of Nuclear Imaging for Cardiac Resynchronization Therapy
title_short The Use of Nuclear Imaging for Cardiac Resynchronization Therapy
title_sort use of nuclear imaging for cardiac resynchronization therapy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2848349/
https://www.ncbi.nlm.nih.gov/pubmed/20425175
http://dx.doi.org/10.1007/s11886-010-0086-9
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