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Selection on Alleles Affecting Human Longevity and Late-Life Disease: The Example of Apolipoprotein E
It is often claimed that genes affecting health in old age, such as cardiovascular and Alzheimer diseases, are beyond the reach of natural selection. We show in a simulation study based on known genetic (apolipoprotein E) and non-genetic risk factors (gender, diet, smoking, alcohol, exercise) that,...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2010
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2848859/ https://www.ncbi.nlm.nih.gov/pubmed/20368805 http://dx.doi.org/10.1371/journal.pone.0010022 |